Eight years ago, Spencer Cox died of #AIDS. He had access to #antiretroviral therapy, but in his own struggles with #depression and substance use, he stopped taking them. 1/
More from Gregg Gonsalves
And this pathetic move by @JDVance1 isn't what is so odious about him. He's just a phony, all ambition, no real interest in public service. He made a big show out of moving back to #Ohio to start a group to work on the #opioid epidemic. 1/
I work on the opioids, on research on the epidemic, its relationship with HIV/HCV, overdose. I work with data from Ohio, so care deeply about what is going on there. I was excited. Until I started digging. There's no there there. 2/
More here. 3/
You can even read their IRS-990-N filing. Sure looks like @JDVance1 tried real hard on combatting the opioid epidemic in his state. Um. Not. 4/
Now he's moved on to venture capital. Money is more interesting than the suffering of the people of #Ohio I guess. 5/
Serious question: I have to go to New York soon and I'm trying to figure out where to stay. I have heard it's disgusting and violent there. But is it like Walking Dead Season 1 or Season 4?
— J.D. Vance (@JDVance1) July 11, 2021
I work on the opioids, on research on the epidemic, its relationship with HIV/HCV, overdose. I work with data from Ohio, so care deeply about what is going on there. I was excited. Until I started digging. There's no there there. 2/
More here. 3/
You can even read their IRS-990-N filing. Sure looks like @JDVance1 tried real hard on combatting the opioid epidemic in his state. Um. Not. 4/
Now he's moved on to venture capital. Money is more interesting than the suffering of the people of #Ohio I guess. 5/
Important tweet from @jaketapper. One amendment: mainstream media will try to change the subject too. It's not a new criticism, the deferential spirit among the political press corps has been noted since Didion wrote about it in the 1990s.
"Those who talk to Mr. Woodward, in other words, can be confident that he will be civil (“I too was growing tired, and it seemed time to stand up and thank him”), that he will not feel impelled to make connections between..." 1/
"what he is told and what is already known that he will treat even the most patently self-serving account as if untainted by hindsight..." 2/
"In this business of running the story, in fact in the business of news itself, certain conventions are seen as beyond debate. “Opinion” will be so labeled, and confined to the op-ed page or the Sunday-morning shows." 3/
"'News analysis' will be so labeled, and will appear in a subordinate position to the 'news' story it accompanies. In the rest of the paper as on the evening news, the story will be reported “'impartially,' the story will be 'even-handed,' the story will be 'fair.'” 4/
We\u2019re beginning to see what will likely be a Herculean effort by MAGA media and certain pols to change the subject from their grotesque assault on democracy, one that resulted in bloodshed and the death of a police officer. Be aware of what they\u2019re doing as they try.
— Jake Tapper (@jaketapper) January 10, 2021
"Those who talk to Mr. Woodward, in other words, can be confident that he will be civil (“I too was growing tired, and it seemed time to stand up and thank him”), that he will not feel impelled to make connections between..." 1/
"what he is told and what is already known that he will treat even the most patently self-serving account as if untainted by hindsight..." 2/
"In this business of running the story, in fact in the business of news itself, certain conventions are seen as beyond debate. “Opinion” will be so labeled, and confined to the op-ed page or the Sunday-morning shows." 3/
"'News analysis' will be so labeled, and will appear in a subordinate position to the 'news' story it accompanies. In the rest of the paper as on the evening news, the story will be reported “'impartially,' the story will be 'even-handed,' the story will be 'fair.'” 4/
More from Health
Sarcomeres in cardiac myocytes (heart muscle cells) are mechanically coupled to focal adhesions through dorsal stress fiber-like structures. #cardiotwitter #CellBiology
1/13
A thread based on Figure 1
A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13
Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13
Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13
The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13
1/13
A thread based on Figure 1
A mature adult cardiac myocyte is packed with sarcomeres, whose contractile forces are coupled to the extracellular environment. With sarcomeres so close to the plasma membrane, how can we study the nature of this coupling?
2/13
Short answer: find a model system where the sarcomeres are not so close to what the cardiac myocyte is attached to. Enter, iPS cell-derived cardiac myocytes. These are “immature” in culture as they resemble fetal or neonatal cardiac myocytes.
3/13
Our previous work on iPS cardiac myocytes reported that sarcomere containing myofibrils assembled on the top surface of the myocyte.
https://t.co/xIBCu3hG1W
4/13
The sarcomeres seemed to be connected to focal adhesions on the bottom of the cell by thin actin bundles that resembled the dorsal stress fibers (DSF) commonly found in non-muscle cells. This movie steps through a Z stack of a myocyte starting at the bottom of the cell.
5/13