https://t.co/k64NSFoaR3
1/n How come we still have academics sustaining narratives of #obesity rather than of how real people find value & meaning in everyday lives? Revisit @whatsthepont on @tobyjlowe / @snowded & accept criticising "neoliberal" does not make things
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If we're going to "Bring the Early Years Expert out of the Shadows" we might start by linking #ECSDNConference2021 practitioners with @greg_dryer / @meaningfulPE in critique of the nonsensical CMO "60 minute" guidelines. PLEASE review @fhcappg session \U0001f447https://t.co/CFC61gNrsG https://t.co/I2mO6BwcZ0 pic.twitter.com/KFC65fSKco
— Greg Spencer (@SingleBlade1) January 22, 2021
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Across a LOT of sectors, good people are facing up to difficult truths about how our own, well-meaning initiatives have entrained outlooks which are perhaps more part of the problem than part of the solution.
— Greg Spencer (@SingleBlade1) December 30, 2020
Where's different? @GmMoving & @PAA_TOP? \U0001f914
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Anthropology meeting the Early Years to challenge lazy thinking around inclusion - inspiring presentation c/o Marco Antonio Delgado-Fuentes - "A historical review of the anthropology of play, games and toys: Are we ready to welcome everyone in nurseries"\U0001f60d #ECSDNConference2021 pic.twitter.com/91ZNJLaRsw
— Greg Spencer (@SingleBlade1) January 22, 2021
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Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs