Previously, the AoN involved a team (usually physio, OT, SLT, psychology) assessing a child to get insight into the nature of their difficulties (2/n)
A thread on the Assessment of Need: the statutory process by which children whose parents have concerns about potential disability can be assessed.
The process has recently been changed by the HSE in a manner that is frankly appalling.
Explanation: (1/n)
Working with colleagues to finalise report on psychologists experiences of AON PTA
— Mark Smyth (@psychpolis) January 17, 2021
Prelim findings are conclusive & stark but not unexpected
\u27a1\ufe0fDoes not meet children's needs
\u27a1\ufe0fIs not fit for purpose
\u27a1\ufe0fWill result in longer intervention W/L
\u27a1\ufe0fShould be suspended immediately pic.twitter.com/7nP59B4hLP
Previously, the AoN involved a team (usually physio, OT, SLT, psychology) assessing a child to get insight into the nature of their difficulties (2/n)
Function is more important than diagnosis, but in our system diagnoses get you support.
(4/n)
In many parts of the country, including Dublin, this almost never happens.
91% of children do not get their assessments on time. (5/n)
https://t.co/LQseHEWj3u
In Jan 2020, the HSE produced a new Standard Operating Procedure for AoN.
It reduces the previous assessment involving multiple professionals to a single assessment lasting a maximum of 90 minutes, regardless of the child's needs. (6/n)
This is left for community disability teams, whose assessments are not subject to legal time limits (so the HSE cannot be sued).
https://t.co/zp5pgO0AHV
Instead, the HSE have reduced the AoN to a meaningless box ticking exercise which children must go through before being moved to another waiting list with no legal time limit. (9/n)
It is apparently more important that statutory obligations are "met" on paper than that children's needs are actually met in real life.
This is a State apology in waiting.
More from For later read
https://t.co/w7koHyMJjL
The article mentions a “10 nucleotide linker” (GCAUAUGACU) in the poly-A tail. This is described in the patent link below (Modification of RNA, producing an increased transcript stability and translation
Here is a link to the full mRNA code if you wish to download it, blast it or make up a batch in your garage
The mRNA sequences used for Moderna mRNA-1273 & Pfizer BNT162b2 mRNA vaccines for COVID-19 (Direct link in Word Format). WHO International Nonproprietary Name Program # 11889 "Messenger RNA encoding the full-length SARS-CoV-2 spike glycoprotein"https://t.co/zTb7B0Apic pic.twitter.com/8tZxAZWI5S
— Roland Baker (@RolandBakerIII) December 24, 2020
An overview of the encoded spike
Moderna's mRNA-1273 & Pfizer's BNT162b2 consist of mRNA 3821 nucleotides long encoding *all* 1273 amino acids of the Spike including a 2 Proline-stabilized RBD and this includes the NTD (blue in monomer, dark gray in trimer attached to antibodies). AA 64, 66, 187, 213, 214 red. pic.twitter.com/4MX1ByAsrR
— Roland Baker (@RolandBakerIII) December 19, 2020
Initial mouse
News: NIH-Moderna investigational COVID-19 vaccine shows promise in mouse studies https://t.co/7JYuUyZT45
— NIH (@NIH) August 5, 2020
Introducing our new series: “IDFN top 10 articles every fellow should read”🔖
#1: SAB management
by @mmcclean1 @LeMiguelChavez
Reviewers @KaBourgi, @IgeGeorgeMD, @Courtcita, @MDdreamchaser
We know is subjective & expect feedback/future improvements 👇
1. Clinical management of Staphylococcus aureus bacteremia: a review.
https://t.co/9tBCtp9mlP
👉 A must read written by Holland et al. where they review the evidence of the management of SAB.
2. Impact of Infectious Disease Consultation on Quality of Care, Mortality, and Length of Stay in Staphylococcus aureus Bacteremia: Results From a Large Multicenter Cohort Study.
https://t.co/XujO68pCuH
👉ID consult associated with reduced inpatient mortality.
3. Predicting Risk of Endocarditis Using a Clinical Tool (PREDICT): Scoring System to Guide Use of Echocardiography in the Management of Staphylococcus aureus Bacteremia
https://t.co/otcA1pxjAw
👉Predictive risk factors for infective endocarditis, and thus the need for TEE.
4. The Cefazolin Inoculum Effect Is Associated With Increased Mortality in Methicillin-Susceptible Staphylococcus aureus Bacteremia.
https://t.co/CQZiryVWZz
👉Presence of cefazolin inoculum effect in the infecting isolate was associated with an increase 30-day mortality.