Affordable transportation. Reliable & built to last (with 10 year warranties). Fun and easy to ride every day. https://t.co/o69kOT19YX
Here's our Sunday Wrapup
- Our 2021 Spring Previews are out (will be linked below
- Bike shortages will be a real thing this year. We're already feeling it with some brands.
- We're upset/scared/frustrated about Covid, and are limiting appointments to urgent repairs only.
Affordable transportation. Reliable & built to last (with 10 year warranties). Fun and easy to ride every day. https://t.co/o69kOT19YX
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Good availability on most models, limited availability on Arroyo Elite and EasyFlow
https://t.co/hZWhj1VLn8
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So many amazing choices to have fun with your family while getting stuff done. Our family is rolling with a Larry vs Harry Bullitt, and a Tern GSD in 2021. https://t.co/mwC2oeDbru
This is a new opportunity for local businesses to take advantage of an incredible $2000 grant toward an electric cargo bike. We're here to consult with you on the best way to move your business forward, on a bike!
https://t.co/zpdXVKJB48
https://t.co/X5EYGtQGy6
Cafe will be closed (again... sigh...).
More from For later read
the whole point of Dunks was you could go cop them at VIM whenever you wanted for $65. this shit is like having to enter a raffle to buy milk.
like seriously why not make a ton more of them if they're gonna be so sought-after? they land at outlets? so? nike still makes money off that.
the only reason to keep making them so limited is that they KNOW all that matters is the profit on the flip and if they were readily available FEWER people would want them, not more
the whole system is super broken, but it's just gonna go the way it goes, because at this point it all caters to the secondary market. the only reason Nike can sell Jordan 1s for $200 is because the people buying them can flip them for $500
adjusted for inflation, a $65 AJ1 in 1985 is like $160—and modern-day AJ1s are made from cheaper materials in factories staffed by cheaper workers. they don't HAVE to be $200 retail. but the secondary market nuked the whole concept of what sneakers are "worth"
\U0001f91e ONLINE RAFFLE is available from @bodega for the upcoming "UNLV" Nike Dunk Low Retro. Open until 5 PM ET on 2/16.
— Kicks Deals (@KicksDeals) February 15, 2021
\u27a1\ufe0f\u27a1\ufe0f https://t.co/JxJlyPuJVo pic.twitter.com/zenWOCDg4L
like seriously why not make a ton more of them if they're gonna be so sought-after? they land at outlets? so? nike still makes money off that.
the only reason to keep making them so limited is that they KNOW all that matters is the profit on the flip and if they were readily available FEWER people would want them, not more
the whole system is super broken, but it's just gonna go the way it goes, because at this point it all caters to the secondary market. the only reason Nike can sell Jordan 1s for $200 is because the people buying them can flip them for $500
adjusted for inflation, a $65 AJ1 in 1985 is like $160—and modern-day AJ1s are made from cheaper materials in factories staffed by cheaper workers. they don't HAVE to be $200 retail. but the secondary market nuked the whole concept of what sneakers are "worth"
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs