My thoughts on 1-dose vs 2-dose approach.

TL; DR

Wrong questions give you wrong answers.

We assuredly should want 2 doses, the only issue is the timing of 2nd dose. And a brief delay is a risk worth taking.

But let's prioritize >65 year old 2nd doses at same time.

1/9

First, let's start with @VirusesImmunity brilliant thread:

We know enough to know that there is vast benefit from giving substantial immunity to as many as possible as quickly as possible. 2/9

https://t.co/QRHx198wkd
We also know that the timing of second dose was never set in stone. Pfizer chose to give second dose at 19-23 days; Moderna chose at 28-31 days. They tested at these levels and proved safety and efficacy. Safety is not at issue with delayed dosing. Efficacy probably is.

3/9
Most of medicine, as practiced, has not been subjected to rigorous clinical trials for various reasons. We weigh available evidence & act accordingly. We pivot when new evidence is available. We should want more RCTs, but they are often unethical or impossible to perform. 4/9
Ideally, Pfizer &/or Moderna would have already done a single dose arm. JNJ is testing both a single-dose & 2-dose regimen. We will have some data in a few weeks on the 1-dose regimen.

But we don't live in an ideal world. We live in the real world. 5/9

https://t.co/oEpNWM6k1p
"Reserving" the second dose undermines our ability to vaccinate the most vulnerable as quickly as possible. We know that many people won't even show up for their second dose (we want to avoid this, but we have seen this with other 2-dose regimens). 6/9 https://t.co/YdLdfhH45A
We don't have to be dogmatic. We can be evidence-based but also practical. We know that the elderly have a reduced immune response to a single dose compared with younger individuals. We can prioritize an earlier second dose for them (>65 year olds). 7/9 https://t.co/lX8bu7UPcX
Bear in mind JNJ vaccine may well get EUA in early February, doubling immediate vaccination capacity with single-dose regimen (hopefully!); AstraZeneca is also still a realistic option in near future.

We ABSOLUTELY should collect data (preferably RCT) on 1- versus 2-dose. 8/9
We seemingly gain a LOT from delaying (for some) the second shot by a short interval (perhaps just a few weeks ). The risk to "reserving" vast numbers of doses, while rampant spread occurs seems HIGHER than the alternative.

Let's put logic & science ahead of dogma. 9/end

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How I created content in 2020

A thread...

Back in Aug 2016, I started creating content to share my experiences as an entrepreneur.
Over 3 years I had put out 1,200+ hours of content - posting every week without


Little did I know that something I started almost 4 years back would give my life an entirely new direction.

At the end of 2019, my biggest platform was LinkedIn with ~700K followers.

In Jan 2020, I decided to build a team that would help me with the content.

I ran a month long recruitment drive to hire a team of interns.

It comprised 4 detailed rounds - starting with my loved 20 questions, then an assignment, then a WhatsApp video round and finally F2F.

Through 1,200+ applications, I finally selected 6 profiles, starting March.

I am a firm believer in @peterthiel's one task, one person philosophy
So the team was structured such that everyone was responsible for ONLY one task

1. Content ideas
2. Videography
3. Video editing
4. LinkedIn (+TikTok) distribution
5. FB+IG distribution
6. YouTube distribution
Every single public defender. Every single day.


Bail arguments, motions, oral arguments, hearings. Judges don’t know, follow, or care about the law. Prosecutors are willing to take advantage of it. And mandatory minimums, withheld evidence, & pretrial detention coerces people to plead before trial. When theres a jury. A shot.

But defenders still fight. And still win. Most times wins aren’t “Justice.” It’s power of repetition of argument in front of same judges. Introducing those in power to the people they oppress. Not just a RAP sheet or words on a page. Defenders make it harder to be brutal & cruel.

I worked as a public defender at an office as well resourced as any in the country. Social workers, team of investigators, a reentry team, support staff, specialist attorneys in immigration, housing, education, family. Relatively low caseloads (80-100). And yet still injustice.

Most think that balancing the scales of justice means more funding for defenders. Thats part of it. Enough a attorneys to actually be at bail hearings. Wrap around services to be able to help people trapped in the system end up better off in their communities. Lower caseloads.

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Where to begin?

So our new Secretary of State Anthony Blinken's stepfather, Samuel Pisar, was "longtime lawyer and confidant of...Robert Maxwell," Ghislaine Maxwell's Dad.


"Pisar was one of the last people to speak to Maxwell, by phone, probably an hour before the chairman of Mirror Group Newspapers fell off his luxury yacht the Lady Ghislaine on 5 November, 1991."
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OK, so that's just a coincidence. Moving on, Anthony Blinken "attended the prestigious Dalton School in New York City"...wait, what? https://t.co/DnE6AvHmJg

Dalton School...Dalton School...rings a

Oh that's right.

The dad of the U.S. Attorney General under both George W. Bush & Donald Trump, William Barr, was headmaster of the Dalton School.

Donald Barr was also quite a


I'm not going to even mention that Blinken's stepdad Sam Pisar's name was in Epstein's "black book."

Lots of names in that book. I mean, for example, Cuomo, Trump, Clinton, Prince Andrew, Bill Cosby, Woody Allen - all in that book, and their reputations are spotless.
Department List of UCAS-China PROFESSORs for ANSO, CSC and UCAS (fully or partial) Scholarship Acceptance
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2) UCAS School of mathematical sciences Professor

3) UCAS School of nuclear sciences and technology
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6) Geotechnical Engineering Teaching and Research Office
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7) Multi-scale Mechanics Teaching and Research Section
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😎 Microgravity Science Teaching and Research

9) High temperature gas dynamics teaching and research section
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10) Department of Biomechanics and Medical Engineering
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12) Department of Dynamics and Advanced Manufacturing
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