1/31 Lots of media coverage, rightly, on huge NHS pressure. What’s cause of, and how widespread, is pressure? How is NHS responding? How serious is this & what’s impact on patients & staff? What’s likely to happen over next few weeks? Long new explainer thread below in two parts.
https://t.co/N2xPmllxY6
More from For later read
Humans inherently like the act of solidarity. We are social beings. We like to huddle up and be together.
They used this against us.
They convinced us that it was an act of solidarity to flatten the curve, to wear a mask for others, to take the vaccines for others,
and to reach #covidzero for others. They convinced us that this was for the greater good of society.
In reality, this couldn't be further away from the truth. They have divided us and broken the core structure of our society. They have dehumanized us with their masks.
They set us against each other into clans on opposite sides of a spectrum. They have turned us into aggressive beings fighting for our survival. Some of us fear harm from the virus, others fear harm from the vaccine, and yet others fear harm from the attack on our civilization.
We are all on a flight or fight mode. We are all operating under the influence of fear. We must collect ourselves and reflect on what has happened over the last year.
How is this for the greater good of society?
They used a tactical warfare strategy against us.
'Divide and conquer'.
We fell for it.
Now we must become aware of it and fight back.
We must reunite. We must find true solidarity to save our world. To free ourselves. To regain our autonomy.
They used this against us.
They convinced us that it was an act of solidarity to flatten the curve, to wear a mask for others, to take the vaccines for others,
If there was ever a time in our lifetime to be non-partisan and for citizens of all walks of life globally to unite behind the basic fundamentals of humanity, freedoms, liberties, human rights, sovereignty, autonomy, dignity, empathy and compassion: it is now. https://t.co/Fa3ieEq51x
— Kulvinder Kaur MD (@dockaurG) January 9, 2021
and to reach #covidzero for others. They convinced us that this was for the greater good of society.
In reality, this couldn't be further away from the truth. They have divided us and broken the core structure of our society. They have dehumanized us with their masks.
They set us against each other into clans on opposite sides of a spectrum. They have turned us into aggressive beings fighting for our survival. Some of us fear harm from the virus, others fear harm from the vaccine, and yet others fear harm from the attack on our civilization.
We are all on a flight or fight mode. We are all operating under the influence of fear. We must collect ourselves and reflect on what has happened over the last year.
How is this for the greater good of society?
They used a tactical warfare strategy against us.
'Divide and conquer'.
We fell for it.
Now we must become aware of it and fight back.
We must reunite. We must find true solidarity to save our world. To free ourselves. To regain our autonomy.
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"I lied about my basic beliefs in order to keep a prestigious job. Now that it will be zero-cost to me, I have a few things to say."
We know that elite institutions like the one Flier was in (partial) charge of rely on irrelevant status markers like private school education, whiteness, legacy, and ability to charm an old white guy at an interview.
Harvard's discriminatory policies are becoming increasingly well known, across the political spectrum (see, e.g., the recent lawsuit on discrimination against East Asian applications.)
It's refreshing to hear a senior administrator admits to personally opposing policies that attempt to remedy these basic flaws. These are flaws that harm his institution's ability to do cutting-edge research and to serve the public.
Harvard is being eclipsed by institutions that have different ideas about how to run a 21st Century institution. Stanford, for one; the UC system; the "public Ivys".
As a dean of a major academic institution, I could not have said this. But I will now. Requiring such statements in applications for appointments and promotions is an affront to academic freedom, and diminishes the true value of diversity, equity of inclusion by trivializing it. https://t.co/NfcI5VLODi
— Jeffrey Flier (@jflier) November 10, 2018
We know that elite institutions like the one Flier was in (partial) charge of rely on irrelevant status markers like private school education, whiteness, legacy, and ability to charm an old white guy at an interview.
Harvard's discriminatory policies are becoming increasingly well known, across the political spectrum (see, e.g., the recent lawsuit on discrimination against East Asian applications.)
It's refreshing to hear a senior administrator admits to personally opposing policies that attempt to remedy these basic flaws. These are flaws that harm his institution's ability to do cutting-edge research and to serve the public.
Harvard is being eclipsed by institutions that have different ideas about how to run a 21st Century institution. Stanford, for one; the UC system; the "public Ivys".
Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs