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Moderna's mRNA-1273 & Pfizer's BNT162b2 consist of mRNA 3821 nucleotides long encoding *all* 1273 amino acids of the Spike including a 2 Proline-stabilized RBD. This is a plain English Description of the code:
https://t.co/w7koHyMJjL

 The article mentions a “10 nucleotide linker” (GCAUAUGACU) in the poly-A tail. This is described in the patent link below (Modification of RNA, producing an increased transcript stability and translation efficiency)
https://t.co/pC8nynqjNv
Here is a link to the full mRNA code if you wish to download it, blast it or make up a batch in your garage lab:
https://t.co/SrTUKYleGn
An overview of the encoded spike protein:
https://t.co/4hSPjnwd6m
Initial mouse studies:
https://t.co/6WwNBrkIU6
The Pfizer-BioNTech vaccine’s brand name is now Comirnaty. koe mir' na tee
https://t.co/aITEWhBnaH
The backstory on mRNA vaccines:
https://t.co/t8kY76pbQc
More History:
https://t.co/R4dvvSofB2
Understanding optimized Modulation of untranslated regions (UTRs):
https://t.co/RttDHCO11j
Understanding codon optimization and why we prefer G & C
https://t.co/NQ3W2RaV3Z

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Abir Ballan \U0001f60a
Abir Ballan 😊
@abirballan
The ten points of the Nuremberg Code
1) The voluntary consent of the human subject is absolutely essential.

2) The experiment should be such as to yield fruitful results for the good of society, unprocurable by other methods or means of study, and not random and unnecessary in nature. 2/n

3) The experiment should be so designed and based on the results of animal experimentation and a knowledge of the natural history of the disease or other problem under study that the anticipated results will justify the performance of the experiment. 3/n

4) The experiment should be so conducted as to avoid all unnecessary physical and mental suffering and injury. 4/n

5) No experiment should be conducted where there is an a priori reason to believe that death or disabling injury will occur; except, perhaps, in those experiments where the experimental physicians also serve as subjects. 5/n
FOR LATER READ
Sahil Bloom
Sahil Bloom
@SahilBloom
Survivorship Bias 101

History is written by the victors. But if we exclusively focus on these successes, we allow survivorship bias to distort our understanding of the world.

But what is "survivorship bias" and how does it work?

Here's Survivorship Bias 101!

👇👇👇


1/ First, a few definitions.

Survivorship bias is the logical error of concentrating on survivors (successes) and ignoring casualties (failures).

When we do so, we miss the true "base rates" of survival (the actual probability of success) and arrive at flawed conclusions.

2/ When we completely ignore failures, we lose our ability to correctly identify the differences between successes and failures.

Put simply, exclusively focusing on successes may actually inhibit our ability to identify (and replicate) the actions that led to such success.


3/ Cicero wrote on the topic over 2,000 years ago.

An atheist named Diagoras is shown portraits of people who prayed and were saved from death at sea as proof of God's existence.

Diagoras replies, "I see those who were saved, but where are those painted who were shipwrecked?"


4/ Cicero cuts right to the point - we cannot conclude that prayer led to being saved from the sea if we ignore those who prayed and then drowned.

Survivorship bias can lead to a deeply-flawed understanding of cause-and-effect relationships.

Let's look at some examples.
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David Boxenhorn
David Boxenhorn
@davidboxenhorn
1. The death of Silicon Valley, a thread

How did Silicon Valley die? It was killed by the internet. I will explain.

Yesterday, my friend IRL asked me "Where are good old days when techies were


2. In the "good old days" Silicon Valley was about understanding technology. Silicon, to be precise. These were people who had to understand quantum mechanics, who had to build the near-miraculous devices that we now take for granted, and they had to work

3. Now, I love libertarians, and I share much of their political philosophy. But you have to be socially naive to believe that it has a chance in a real society. In those days, Silicon Valley was not a real society. It was populated by people who understood quantum mechanics

4. Then came the microcomputer revolution. It was created by people who understood how to build computers. One borderline case was Steve Jobs. People claimed that Jobs was surrounded by a "reality distortion field" - that's how good he was at understanding people, not things

5. Still, the heroes of Silicon Valley were the engineers. The people who knew how to build things. Steve Jobs, for all his understanding of people, also had quite a good understanding of technology. He had a libertarian vibe, and so did Silicon Valley
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The Reckoning \U0001f4a5
The Reckoning 💥...
@sethjlevy
1/ The reality is that when Boehner and McConnell joined the Democrats in 2010, to thwart the impact of the tea party, they broke trust with the base.
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GAVNet
GAVNet
@GAValueNetwork
Daily Bookmarks to GAVNet 02/12/2021

Quantum causal loops

https://t.co/emX8OxKPl0

#loops #quantum

Large-scale commodity farming accelerating climate change in the Amazon

https://t.co/v3gA7OTP9E

#ClimateChange #forest #farm

Collapsed glaciers increase Third Pole uncertainties: Downstream lakes may merge within a decade

https://t.co/huAma56KeB

#glacier #lakes #ClimateChange

From trash to treasure: Silicon waste finds new use in Li-ion batteries

https://t.co/TkxKFDQMC6

#batteries #treasure #silicon #trash
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Peter McCormack [Jan/3\u279e\u20bf \U0001f511\u220e]
Peter McCormack [Jan/3...
@PeterMcCormack
1/ So here is a thread on how I turned $32,000 into $1.2m and back to pretty much zero (once taxes are paid).

Just note, I am not bitter or salty in any way at all, the last 2 years have been an amazing ride - travelled the world, been wealthy, been poor.

2/ Dec '16, my advertising agency folded, I had a little bit of money left and I put $32k into Bitcoin and Ether. As it started to go up I diversified into everything, Monero, Dash, this that, any crap - even Ripplecoin. Everything just kept going up.

3/ By March I think I had around $300k and $500k by the summer. I used to take 25% out but towards the end of the summer I got greedy and put it all back in and by December it was $1.2m.

4/ Thinking I was an absolute genius I decided to start a bunch of businesses. As silly as it sounds I had this goal of making $5m as I wanted to buy Bedford Town Football Club and get them in the league, and as Crypto was going up forever I needed 6 months.

5/ So:
- Trading (income 1)
- Podcast (income 2)
- Mining (income 3)
- Mining pool (income 4)
- Consulting (income 5)

Yes - all of the above as a one-man army :)
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Bharadwaj
Bharadwaj
@BharadwajSpeaks
Today is Jayanti of Ahilyabai Holkar

She was a widow who became Malwa's greatest queen. Defended our country & personally led armies into battle.Never plundered anyone. Developed Malwa into a prosperous kingdom. Rebuilt temples destroyed by Mughals. Built Dharmashalas at Tirthas


Unfortunately, her memory has been blemished by inaccurate representations in modern popular media.

The serial "Punyashlok Ahilyabai" depicts her as ultra secularist feminazi icon who questions Hindu rituals & Pandits while patronising Sufis.

This is far from historical truth!


Ahilyabai was born on May 31 1725 to Patil Mankoji Shinde.

She was from Dhangar clan(classified as OBC today). While Dhangars were traditionally into herding, they took up arms & held several military /civil roles in various eras of history(especially during Maratha resurgence)


In 1737, when she was 12, Ahilyabai Holkar was married to Khanderao , son of Subedar Malhar Rao Holkar.

By the time she was married, fortunes of Holkar family had already waxed.

Malhar Rao was a Subedar of territory comprising 30 Parganas yielding a revenue of at least 7 Lakh


In 1741, when Ahilyabai was newly married, her father -in-law Malhar Rao Built Indore palace & ordered the kanungo to populate the settlement with a promise of protection to traders.

This began rise of Indore from its background as modest trading town Indrapuri to a great city
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Seth Abramson
Seth Abramson
@SethAbramson
(THREAD) The Whitaker scandal is deepening, as it becomes clear that Sessions' Russia recusal was a coordinated sham and his firing an act of obstruction—and that his replacement is a White House plant inside the Mueller probe. I hope you'll retweet and read on for more details.


1/ From 2014-17 Whitaker worked for World Patent Marketing—which during his tenure defrauded consumers out of $26 million and was successfully prosecuted by the feds. His involvement in the scam confirmed he had loose morals and that the feds would never want to employ him again.

2/ Despite the seeming impossibility of a man with Whitaker's background getting a job at Justice ever again—he'd been found to have used his former title as a US attorney to fraudulently threaten consumers with valid complaints with criminal penalties—Whitaker found an opening.

3/ Within 60 days of parachuting out of World Patent Marketing as it was being fined $26 million by the feds, Whitaker was working for CNN and telling a fellow attorney panelist that his purpose in working for CNN was to get noticed by one man—Donald Trump—and thereby get a job.

4/ Whitaker spent his time at CNN making ludicrous statements about the Mueller probe: there was no obstruction or collusion, he said; Mueller had no authority to look into any aspect of Trump's finances or to subpoena him, he said. All the while, he hoped Trump was watching him.
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Zach Weinersmith
Zach Weinersmith
@ZachWeiner
Hey, for people interested in this stuff, here's a thread about a change we made to running our facebook account:

So, about 5 years ago, we got on facebook. Why? Well, facebook has a big audience and they like to consume on facebook. So, we started posting comics there, even though we got paid nothing and facebook made money off the free content.

Why? Because back then, once in a while, you would say "also hey, I sell books" or "hey, I'm going to be signing at this event" and your facebook followers would actually see it.

Effectively, the implicit old arrangement was "facebook lets me reach readers efficiently, and I supply facebook with free content they run ads on."

Over time, like a bad business partner, facebook basically made it impossible to reach your audience without *paying them*. Thus, you supply them free content on which they run ads, and you get nothing in exchange.
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Enough Jaw Jaw, this is War!
1. People's Justice Courts to be set up worldwide
2. Citizens' arrests of all Identified Suspects
3. Lab Inspections
3. Harsh interrogation using MKULTRA
4. Public Show Trials video streamed live
5. Cross Questioning of suspects via Twitter & Zoom
6.


A growing list of suspects to be interrogated


Foul Traitors, Charlatans, Frauds, Bat Molesters! Frankensteins, Well Poisoners, Plotters, Deceivers!
Dr. Shipmans, Saboteurs, Devils in White Coats!


Organisations to be Investigated
WIV
Wuhan University IMA
WIBP
WCDC
BEIJING IPB
Nanjing Military Lab
SinoPharm
BARDA
NIH
EMERGENT BIOSOLUTIONS
BIOPORT
GILEAD
SIAC
QTEL
USAMRIID
FORT DETRICK
DARPA
DTRA
Metbiota
ONE HEALTH
GVP
ECOHEALTH
MITRE
BATTELLE
TUNNELL
LAURIMA GOV SERVICES


Suspects (1)
China
Zhengli Shi
Peng Zhou
George Gao
Deyin Guo
Major General Chen Wei
United States
ALEX AZAR
JONNA MAZET
ALISON O’TOOLE
ANTHONY FAUCI
BOYD YOUNT
DAVID FRANZ
DAVID KARESH
DENNIS CARROLL
DYLAN GEORGE
GEORGE PAINTER
IAN LIPKIN
JENS KUHN
JEROME HAUER
JONATHAN EPSTEIN
WORLD , ALL