"How Drug Companies mislead doctors and harm patients?"

This is a title of a book written by a British physician Ben Goldacre.

One of the famous example cited by him is an example of one particular antidepressant reboxetine.

Only one trial of this was published out of seven when tested against a 'placebo'. Obviously the trial published found it to be effective and the remaining six trials remained unpublished.

What were these unpublished trials like?
The same antidepressant was tested against serotonin reuptake inhibitors. It was proved in this trial that the particular antidepressant was not only less effective but also had worse adverse effects.

I'm just citing one such example from the book.
The second major point raised in this book is about how pharmaceutical companies market their products, how they intrude into medical syllabus/education, how they influence the doctors and regulators in supporting their medicines, etc.
My Example:

Colgate-Palmolive Co. announces the publication of the textbook Periodontal Disease and Overall Health: A Clinician’s Guide,Second Edition. 

https://t.co/Rvt1HWdJth
Goldacre continuously and repeatedly emphasizes the harm caused to patients resulting from the biased and incomplete reporting of trials data, and other failures of drug regulation and marketing.
My example:

Female oral contraceptives and hormone therapy drugs all carry an increased risk for blood clot formation. Please read this article for more details:

https://t.co/wtBwlsbXni
The third point raised by him are basically the shortcomings in the design and conduct of clinical trials.

And how these trials seem convincing and well researched.
My example:

Oklahoma's attorney general accused Johnson & Johnson of a "multi-billion-dollar brainwashing campaign" to get doctors to overprescribe opioids, downplaying the addiction risks.

https://t.co/5f26xDwMOb

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#talesofkrishna https://t.co/E85MTPkF9W


Now Suniti was the daughter of a tribal chief while Suruchi was the daughter of a rich king. Hence Suruchi was always favored the most by Raja while Suniti was ignored. But while Suniti was gentle & kind hearted by nature Suruchi was venomous inside.
#KrishnaLeela


The story is of a time when ideally the eldest son of the king becomes the heir to the throne. Hence the sinhasan of the Raja belonged to Dhruva.This is why Suruchi who was the 2nd wife nourished poison in her heart for Dhruva as she knew her son will never get the throne.


One day when Dhruva was just 5 years old he went on to sit on his father's lap. Suruchi, the jealous queen, got enraged and shoved him away from Raja as she never wanted Raja to shower Dhruva with his fatherly affection.


Dhruva protested questioning his step mother "why can't i sit on my own father's lap?" A furious Suruchi berated him saying "only God can allow him that privilege. Go ask him"
THREAD: 12 Things Everyone Should Know About IQ

1. IQ is one of the most heritable psychological traits – that is, individual differences in IQ are strongly associated with individual differences in genes (at least in fairly typical modern environments). https://t.co/3XxzW9bxLE


2. The heritability of IQ *increases* from childhood to adulthood. Meanwhile, the effect of the shared environment largely fades away. In other words, when it comes to IQ, nature becomes more important as we get older, nurture less.
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3. IQ scores have been increasing for the last century or so, a phenomenon known as the Flynn effect. https://t.co/sCZvCst3hw (N ≈ 4 million)

(Note that the Flynn effect shows that IQ isn't 100% genetic; it doesn't show that it's 100% environmental.)


4. IQ predicts many important real world outcomes.

For example, though far from perfect, IQ is the single-best predictor of job performance we have – much better than Emotional Intelligence, the Big Five, Grit, etc. https://t.co/rKUgKDAAVx https://t.co/DWbVI8QSU3


5. Higher IQ is associated with a lower risk of death from most causes, including cardiovascular disease, respiratory disease, most forms of cancer, homicide, suicide, and accident. https://t.co/PJjGNyeQRA (N = 728,160)