BC ALL
Saved by @ankitsrihbti

Why are graphs the future of biomedical research and what is the value of NLP here?

A small case study about:

How to speed up drug discovery with knowledge graphs and discover potential cures for diseases

 In this case text mining is used to contextualize knowledge about:

- Genes
- Compounds
- Diseases
- Adverse drug effects
- Receptor bindings
Which text types are processed here? Medical literature, patient notes, electronic health records, clinical reports etc.

But how to start?

First you need to identify the different entities such as compounds, diseases, adverse drug effects and receptor bindings.
This is achieved through Natural Language Processing (NLP) and there are suitable pre-trained models for processing biomedical, scientific or clinical text like scispaCy

@spacy_io models for processing biomedical, scientific or clinical text
https://t.co/1EPFZCFwoc
Another library which is specialized in biomedical text is Spark NLP

@JohnSnowLabs

https://t.co/EYM8lIyuUp
The next challenge is to extract the different relations! Diseases are related to genes which are related to receptors and compounds can bind to these receptors.

Sounds simple at first but there are several problems that need to be solved
Problems to solve

1. Difficult to ingest and integrate complex networks of text mined outputs
2. Difficult to contextualize knowledge extracted from text with existing knowledge
3. Difficult to investigate insights in a scalable and efficient way
Fortunately, Grakn solves all our problems!

@GraknLabs

How it works is explained here: https://t.co/BCGDuWrVqA
To understand how NLP and graphs are used to link medical knowledge I recommend this talk on text mining and drug discovery at Novartis

Not quite up to date but aged very well

Connecting the Dots in Early Drug Discovery at Novartis
https://t.co/QNJt6q5IsU

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Mitesh Patel
Mitesh Patel
@Mitesh_Engr
Again sharing bank nifty intraday weekly straddle. How to play by selling straddle.
Mostly will work on Monday to Wednesday. Sometimes on Friday.
Why to pay your money to learn this if u can get it here.
U need only practice.
Let’s go.

Say bank nifty future is at 32000.
Sell both 32000 call and put.
Considering current volatile market lest say premium on Monday morning is 350 on both sides.
Sold with 700 points combine premium.
If bank nifty will trade in narrow range say +\- 100 hold it.
If moving 200 points

then exit previous sold straddle. Sell new one. Let’s say BN moved +200
Now sell 32200. If bank nifty will move here within range then u will get profit through theta decay. Follow same procedure for next 150-200 pts move.

This is only for single straddle sell position.

Now in second case sell three straddle. 31900/32000/32100
In case of 100 points move no need to change.
If 200 + then future is 32200.
Exit 31900 and sell 31200 straddle.
If moving another 100 then exit 32000 and sell 32300. Continue same with 100 points move.
If no move then

it will consolidate between 32000-32200 or 32100 to 32300 and u will get theta decay.

This is for normal move. Sudden big move may come anytime. So keep SL in system.
If u r selling at 350-350 then keep SL in system 475 for both legs.
Practice it. No need to attend webinar.
BNF , MPATELOPTIONSLEARNINGS , OPTIONSLEARNING
Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
🌺श्री गरुड़ पुराण - संक्षिप्त वर्णन🌺

हिन्दु धर्म के 18 पुराणों में से एक गरुड़ पुराण का हिन्दु धर्म में बड़ा महत्व है। गरुड़ पुराण में मृत्यु के बाद सद्गती की व्याख्या मिलती है। इस पुराण के अधिष्ठातृ देव भगवान विष्णु हैं, इसलिए ये वैष्णव पुराण है।


गरुड़ पुराण के अनुसार हमारे कर्मों का फल हमें हमारे जीवन-काल में तो मिलता ही है परंतु मृत्यु के बाद भी अच्छे बुरे कार्यों का उनके अनुसार फल मिलता है। इस कारण इस पुराण में निहित ज्ञान को प्राप्त करने के लिए घर के किसी सदस्य की मृत्यु के बाद का समय निर्धारित किया गया है...

..ताकि उस समय हम जीवन-मरण से जुड़े सभी सत्य जान सकें और मृत्यु के कारण बिछडने वाले सदस्य का दुख कम हो सके।
गरुड़ पुराण में विष्णु की भक्ति व अवतारों का विस्तार से उसी प्रकार वर्णन मिलता है जिस प्रकार भगवत पुराण में।आरम्भ में मनु से सृष्टि की उत्पत्ति,ध्रुव चरित्र की कथा मिलती है।


तदुपरांत सुर्य व चंद्र ग्रहों के मंत्र, शिव-पार्वती मंत्र,इन्द्र सम्बंधित मंत्र,सरस्वती मंत्र और नौ शक्तियों के बारे में विस्तार से बताया गया है।
इस पुराण में उन्नीस हज़ार श्लोक बताए जाते हैं और इसे दो भागों में कहा जाता है।
प्रथम भाग में विष्णुभक्ति और पूजा विधियों का उल्लेख है।

मृत्यु के उपरांत गरुड़ पुराण के श्रवण का प्रावधान है ।
पुराण के द्वितीय भाग में 'प्रेतकल्प' का विस्तार से वर्णन और नरकों में जीव के पड़ने का वृत्तांत मिलता है। मरने के बाद मनुष्य की क्या गति होती है, उसका किस प्रकार की योनियों में जन्म होता है, प्रेत योनि से मुक्ति के उपाय...
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
MAHARAANI TARARANI: THE QUEEN OF MARATHAS

Rani Tarabai was the brave daughter-in-law of Chhatrapati Shivaji and one of the greatest medieval Monarchs India ever had.
She was born in 1675 to one of the bravest commander-in-chiefs of Shivaji's Army named Hambir Rao Mohite.


Tarabai was just 8yrs old when she was married to Shivaji's younger son, Rajaram. Mughals and Marathas were constantly at war with each other. Shivaji was crowned the ruler of the Independent Maratha Swarajya in 1674 which was established by him.


However,the great leader died in 1680&the Maratha Samrajya went into a complete&total chaos.Marathas saw some very tough times ahead. In 1689,when Raigad Fort fell to the Mughal Army of over 15000,Shivaji's first wife Saibai and his elder son Sambhaji were captured&put to death.


Sambhaji's wife and son Shahu were taken prisoners to the Mughal court. During the same battle, Shivaji's second son Rajaram(Tarabai's husband) , who was the heir to the throne now, managed to escape using a disguise. He made his way to the Gingee Fort in Tamil Nadu.


Mughal General Zulfikar Khan, however, followed them to Gingee laying siege to the Gingee Fort. From 1690-1698,This was the longest siege by a Mughal Army of any Fort which stands testimony to the military and diplomatic credentials of Rani Tarabai.
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Siddharth Karamcheti
Siddharth Karamcheti
@siddkaramcheti
How can we use language supervision to learn better visual representations for robotics?

Introducing Voltron: Language-Driven Representation Learning for Robotics!

Paper: https://t.co/gIsRPtSjKz
Models: https://t.co/NOB3cpATYG
Evaluation: https://t.co/aOzQu95J8z

🧵👇(1 / 12)


Videos of humans performing everyday tasks (Something-Something-v2, Ego4D) offer a rich and diverse resource for learning representations for robotic manipulation.

Yet, an underused part of these datasets are the rich, natural language annotations accompanying each video. (2/12)

The Voltron framework offers a simple way to use language supervision to shape representation learning, building off of prior work in representations for robotics like MVP (https://t.co/Pb0mk9hb4i) and R3M (https://t.co/o2Fkc3fP0e).

The secret is *balance* (3/12)

Starting with a masked autoencoder over frames from these video clips, make a choice:

1) Condition on language and improve our ability to reconstruct the scene.

2) Generate language given the visual representation and improve our ability to describe what's happening. (4/12)

By trading off *conditioning* and *generation* we show that we can learn 1) better representations than prior methods, and 2) explicitly shape the balance of low and high-level features captured.

Why is the ability to shape this balance important? (5/12)
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Ben Meer
Ben Meer
@SystemSunday
The best morning routine?

Starts the night before.

9 evening habits that make all the difference:

1. Write down tomorrow's 3:3:3 plan

• 3 hours on your most important project
• 3 shorter tasks
• 3 maintenance activities

Defining a "productive day" is crucial.

Or else you'll never be at peace (even with excellent output).

Learn more


2. End the workday with a shutdown ritual

Create a short shutdown ritual (hat-tip to Cal Newport). Close your laptop, plug in the charger, spend 2 minutes tidying your desk. Then say, "shutdown."

Separating your life and work is key.

3. Journal 1 beautiful life moment

Delicious tacos, presentation you crushed, a moment of inner peace. Write it down.

Gratitude programs a mindset of abundance.

4. Lay out clothes

Get exercise clothes ready for tomorrow. Upon waking up, jump rope for 2 mins. It will activate your mind + body.
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libertyandjusticeforall
libertyandjusticeforal...
@Mark923to25
1. #Qanon told us that Saudi Arabia is a central piece of the puzzle in taking out the Deep State...we are watching the Deep State attempt to remove Crown Prince MBS and disrupt Pres Trump's administration's ties with MBS and the "new" Saudi/US coalition. Early in his admin,


2....@Potus sent Jared Kushner (JK) to SA on an undisclosed trip and told King Salman that business as usual was over, and if he wanted Pres Trump's support, Prince Alwaleed would have to be divested of $ and power; Alwaleed is one of top Deep State $ men and was tied to HRC.


3. @Potus knew that before he could begin cleansing the US and the rest of the world of the DS, he would have to cut one of the financial head's off the snake (Alwaleed). After JK met w/ King Salman, Alwaleed was arrested and divested of billions; MBS became leader of SA.


4. SA loves Pres Trump because he's a man of his word; SA could not trust Hussein or Clintons because they use SA for oil and leverage; SA has many factions, but essentially you have the new and upcoming SA that is attempting to modernize through Crown Prince MBS, and then you


5...have the old guard represented by Alwaleed who was one of the Deep State financial heads and loyal to the DS more than SA; SA knew Hussein was financing Iran to hold western world hostage, and SA was caught in middle of Deep State black mail; this is why @Potus was celebrated
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Vibhu Vashisth
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@VIBHU_Tweet
RANI GAIDINLIU:THE LESSER KNOWN FREEDOM FIGHTER

Rani Gaidinliu joined the freedom struggle at 13 &was sentenced to life imprisonment at 16."We r free people—the White should not rule over us.”Thus calling out to her Zeliangrong tribesmen was the voice of 13yr-old Rani Gaidinliu.


She joined the freedom struggle in the present-day Northeast India. Today, her struggle is lost in history as most of her countrymen wouldn’t even have heard her name. B'coz our history textbooks tell us that only Mahatma Gandhi &Pandit Nehru got India its Independence.


At 16 yrs of age, this valiant girl was sentenced to life imprisonment for leading a movement to drive out the colonial rulers from Manipur and Nagaland. Nevertheless, she was released in 1947 after India’s independence and was given the title ,"Rani of Nagas".


EARLY LIFE AND HERAKA MOVEMENT

Gaidinliu belonged to the Rongmei clan of the Zeliangrong tribe in the Tamenglong district of western Manipur. Born on January 26, 1915, she was fifth among eight children.


Her native village was Nungkao, which is present day Tamenglong distt. Brought up in a specially backward region,she couldn't receive any formal education. However,this didn't stop her from joining the freedom struggle. At the age of 10 she came under the influence of her cousin.
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Tej Dosa \U0001f602\U0001f9e0
Tej Dosa 😂🧠...
@ComedicBizman
(A THREAD)

18 Things I Would Do At 18:

I was a dumb 18-year-old. I thought I had the world figured out. I didn't.

I stayed up till the wee hours. Drank every liquor invented.

Partied non-stop. Woke up after noon.

Surfed the web aimlessly.

Read BS self-help.

Repeat.

If I could do it all over again, here's 18 things I would do...

PHASE ONE: GET MY MIND RIGHT

ACTION #1: Break the chains - I wish I made the decision earlier. I didn't. I was scared. Anxious. Nervous. I knew once I made the decision, there was no going back.

Don't be like me.

Make the decision at 18. The decision to pave your own path in life. To go against the herd. To choose your own adventure. To commit to whatever sets your heart on fire.

ACTION #2: Cut off every negative person in your life.

Scroll through the contacts in your phone...

Notice how the names make you feel.

Delete any and all names that fill you with doubt and negativity.

ACTION #3: Condition your mind to embrace the producer mindset instead of the consumer mindset.

Consume 20% of the time. Produce 80% of the time.

Case closed.

ACTION #4: Set an intention to make $10k a month and write it out every MORNING and NIGHT as if you already achieved it (in the past tense).

Visualize yourself already having the money as you write.

Cheesy?

Yes.

Does it work?

Yes.

PHASE TWO: EDUCATION
LIFE
\uff2c\uff41\uff44\uff59 \uff22\uff4c\uff41\uff5a\uff45\uff53
Ｌａｄｙ Ｂｌａｚｅｓ...
@Lady_Blazes
Oh my Goodness!!!

I might have a panic attack due to excitement!!

Read this thread to the end...I just had an epiphany and my mind is blown. Actually, more than blown. More like OBLITERATED! This is the thing! This is the thing that will blow the entire thing out of the water!


Has this man been concealing his true identity?

Is this man a supposed 'dead' Seal Team Six soldier?

Witness protection to be kept safe until the right moment when all will be revealed?!

Who ELSE is alive that may have faked their death/gone into witness protection?


Were "golden tickets" inside the envelopes??


Are these "golden tickets" going to lead to their ultimate undoing?

Review crumbs on the board re: 'gold'.


#SEALTeam6 Trump re-tweeted this.
GOVERNMENT
ArmaniTalks \U0001f399\U0001f525
ArmaniTalks 🎙🔥...
@ArmaniTalks
Your Most PRECIOUS Currencies:

-Energy

-Time

-Attention

-Trust

-Love

-Loyalty

-Respect

Only give these currencies to high value people. Never spend these currencies on low value shitheads eg: trolls, weasels, snakes, naysayers etc.

'Wait, I thought money was the most important currency?'

Nah.

Once you adopt abundance mentality, you realize their is no shortage of money.

Making the dollars your most important currency will have you leading an empty life.

Time to flip your perspective.

👇

▪Energy

When you strip yourself to the core, you are an emotional creature.

Emotions are your internal worlds energy.

Harnessing that energy is crucial for leveraging yourself to obtain whatever you want.

You have a finite amount everyday, so spend it wisely.

▪Time

A second that is lost will never be returned.

You start valuing the hell out of this currency the more you mature.

As the years start adding up, you realize time is precious.

You must always have a scarcity mindset towards time.

Once you do so, you will not be lazy.

▪Attention

You can be here, but not present.

Attention is completely mental.

Giving someone your attention means you are clearing up mental bandwidth to make room for them.

Only give your attention to people who help you grow.

For the negative ones?

Ignore their existence
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