Happy 2021! @MBVanElzakker and I are excited to share our new article published in #Immunometabolism: “Pathogens Hijack Host Cell Metabolism: Intracellular Infection as a Driver of the Warburg Effect in Cancer and Other Chronic Inflammatory Conditions”:

2/ In the paper, we detail molecular mechanisms by which #viral, #bacterial, and #parasite intracellular pathogens can induce, or contribute to, a Warburg-like #metabolism in infected host cells in order to meet their own replication and nutritional needs.

3/ We also discuss how host defense towards #infection may impact cellular metabolic changes (including how #mitochondria can participate in the innate immune response towards infection)

4/ We then provide examples of how many of these same intracellular pathogens have been identified in #tumors, atherosclerotic lesions, #granuloma, and other tissues containing cells with a Warburg or altered metabolism.

5/ Last, we examine further trends associated with infection and host cell metabolism, including how #pathogen-driven hijacking of host cell lipid metabolism can support viral, bacterial, and parasite survival and replication.