7 days 30 days All time Recent Popular
Here's a thread of all of @LLinWood's recent 🔥 tweets for your safe keeping.
This issue is, appropriately, contentious. As a vaccinologist - & citizen & relative of people in at-risk groups - I fully support the UK decision to increase dose intervals of both our Ox/AZ product and the Pfizer product. I'd happily receive either with a >8w gap. Here's why 🧵


For the Ox/AZ vaccine, it's fairly simple. The trial demonstrated efficacy at a range of dose intervals. Antibody responses after the boost were significantly stronger with longer intervals - see table

(so in response to @drmarkporter's point, higher immune responses with a longer interval is proven & now public. I haven't seen a similar analysis for efficacy against disease but the data exists and I suspect the regulators & JCVI committee have)

For Pfizer, there isn't direct evidence of efficacy with a >3wk interval. But as widely publicised, efficacy in the period from 14 days after first dose to 21 days is high.


Can we extrapolate from this to a longer interval? It's a judgment call. On one hand is evidence-based medicine's scepticism of anything not directly proven 'beyond reasonable doubt' in an RCT; on the other is a 'balance of probabilities' approach based upon the biology.
THREAD
There’s much debate around the UK's recommended use of the AZ vaccine with a two-dose schedule and flexible timing of second dose. Some thoughts on the AZ recommendation (not Pfizer) based on available data with refs to some excellent threads.


UK’s MHRA and JCVI are highly-experienced in vaccine assessments and recommendations, and they've surely weighed the benefits & risks of this recommendation carefully. That said, it would be good to see all the data underpinning their recommendation.


In general, vaccines should be taken on a schedule tested in an efficacy trial. But it wasn’t possible to conduct the typical dose and schedule optimization prior to these Ph3 trials, and those trials provided valuable data to inform these recommendations. 3/

The UK recommends a two-dose schedule, with the second dose between 4-12 weeks. This *is not* a single dose schedule. Given the data provided, and in the setting of limited supply, overstretched hospitals, and emergence of a more transmissible variant, this seems justifiable. 4/

The UK has important data on the AZ Vx that wasn’t available for Pfizer & Moderna at FDA's VRBPAC, including:
* single-dose efficacy through 4+ months; and
* single-dose immunogenicity (12+ weeks).
These people are SICK,
TWISTED, EVIL.

After nearly 6 days w/o responding w/ Login Confirmation Code & blocked email,
I'm mysteriously allowed back w/o explanation,
....but appearing as if I follow no one even though I can open & see my Following List.

J sucks! @DanScavino


While I was kept away,
https://t.co/hcHpfQVlT5
this Thread has a few others linked within.

Did you know that MARCH for TRUMP Day 1.06, 2021 falls
894 months, 23 days exactly from
the time of @realdonaldtrump's Birth??
6.14, 1946

A few coincidences Re: Mike Pence
https://t.co/E6Z17oKpsO
were Interdasting.

Does anyone know how long Michael Richard Pence had been using an "8" preceding the Signature from his time in Indiana? Haven't a clue.

https://t.co/1Fa0Tgr2IZ

https://t.co/7xDlptHXgO
Like everyone else Trusting the Plan,

....just as eager to see how the next 16 days play out.

But if TRUMP is the beacon, shouldn't he be worried?
Or not.

The 2016 VIDEO was all about WE, THE PEOPLE reclaiming our governance.

https://t.co/Z1TCytqCzk
Did anyone catch the :03 seconds by POTUS in his Tweet
Re: the Wed 11.00 am Protest March for Trump???

The 11.3 ode quite possibly back to the Deep State even??