The important difference between AstraZeneca's relationship with the UK and with the EU, and the reason it has fallen behind schedule on 50m vaccine doses promised to the EU, is that the UK agreed the deal with AZ a full three months before the EU did - which gave...

AZ an extra three months to sort out manufacturing and supply problems relating to the UK contract (there were plenty of problems). Here is the important timeline. In May AZ reached agreement with Oxford and the UK government to make and supply the vaccine. In fact Oxford...

had already started work on the supply chain. The following month AZ reached a preliminary agreement with Germany, the Netherlands, France and Italy, a group known as the Inclusive Vaccine Alliance, based on the agreement with the UK. The announcement was 13 June. BUT the EU...

insisted that the Inclusive Vaccine Alliance could not formalise the deal. The European Commission insisted it should take over the contract negotiations on behalf of the whole EU. So were another two months of talks and the contract was not signed till the end of August...

What is frustrating for AZ is that the extra talks with the European Commission led to no material changes to the contract, but wasted time on making arrangements to make the vaccine with partner sites. The yield at these partner sites has been lower than expected. The problem...