BC VERY0WNSPIKE
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“John D. Rockefeller is credited as a founder of Pharmaceutical Industry.”
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“Beginning in 1930, the Rockefeller Foundation provided financial support to the Kaisier Wilhelm Institute, Human Heredity, and Eugenics, which later conducted eugenics experiments in the Third Reich.”

 IRS Copy of 990-PF form of The Rockefellers Brothers Fund (2001):
https://t.co/ZH0zo7Lc6b
Grant to "Eleanor Roosevelt Institute Tor Cancer Research - To the research of Kathleen Gardiner, PhD, entitled "A-to-l mRNA Editing of Mammalian Genes Relevance to Learning and Behavior".
Gene regulation by mRNA editing (1995):
https://t.co/K2H1rc2Uvx

"Despite the potential power of mRNA editing to generate new and useful gene products, it is clear that it must be tightly regulated. Unrestricted mRNA processing could lead the cell to synthesize toxic proteins..."
The European Regulatory Environment of RNA-Based Vaccines (2016):
https://t.co/DDFcEYf6nQ

mRNA mediates passive vaccination against infectious agents, toxins, and tumors (2017):
https://t.co/Fj6ZNU7DjA

Enlisting the mRNA Vaccine Platform (2019):
https://t.co/XqjKygr2yR
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues (December 2020):
https://t.co/aY00nqMv5b

'Protecting' from endothelial bio-weapon by leaky temporary mRNA gene-therapy...
The Rockefeller University and Broad Institute of MIT and Harvard announce update to CRISPR-Cas9 portfolio filed by Broad (January 2018):
https://t.co/rn96X5IOlk
"CRISPR-Cas9 system - Drs. Marraffini and Feng Zhang are co-inventors and Rockefeller and Broad are joint owners."
The Rockefeller University - Researchers use new CRISPR-based strategy to replicate disease in cells (May 2016):
https://t.co/usr9s8ECWX
- Making gene editing more reliable

"mRNA is a way to make CRISPR gene editing come alive. CRISPR is the workhorse; mRNA encodes it."
Luciano Marrafini, the Rockefeller University, - Harnessing CRISPR-Cas9 immunity for genetic engineering (2014)
https://t.co/uwmVabxbke

CRISPR's many pioneers (2020):
https://t.co/NXcBrh6wbb

Jennifer Doudna, WEF Agenda Contributor, - CRISPR in 4IR:
https://t.co/XuByFKbzJg
Jennifer Doudna for WEF - Q&A: Towards the end of genetic disease? (2015)
https://t.co/ycIlkFn6dT
"If the Human Genome Project mapped the genetic code, with CRISPR-Cas9 we’re re-writing it."

Francis Collins on CRISPR, mRNA, COVID-19 (March 2021):
https://t.co/OkAtDzQIh6
https://t.co/yHyVBTUkxd
https://t.co/amGqnwA4eE
Boston University - CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool (2018):
https://t.co/MuOHlQ9Hpt
https://t.co/WWZ59Udcyl
The Bid, BlackRock podcast - Moderna and CRISPR Therapeutics on fighting Covid-19 (April 1, 2021):
https://t.co/CNXcuFSsTh

What a joke…
NIH, EcoHealth Alliance, Peter Daszak, U.S. Department of Defense (DARPA) - Understanding the Risk of Bat Coronavirus Emergence (2014-2019):
- https://t.co/cz53OCfZho
- Scientific Research - "Combating Weapons of Mass Destruction":
https://t.co/GBmnP3DlEc
https://t.co/iSR5TAOP03
https://t.co/0iiB82IH3D
DARPA invests $100m in gene-drive technology - new gene-editing technology, which many people fear could lead to deliberate and unintended damage on a huge scale (2017):
https://t.co/MORcxOombn

Harvard, Wyss Institute - CRISPR-Cas9: Gene-drive:
https://t.co/7daNFMZjBo
DARPA - Preventing Pandemics (March 2021)
https://t.co/0CSBJFgv7F

Prevending Pandemics Platform (P3):
https://t.co/Pa88DKGmzh
The Rockefeller University (March 2019):
https://t.co/F6QUXpPK4K
“If a phage has a single point mutation in its target sequence, then usually the virus is invisible to Cas and the infection will succeed,” says Marraffini. “But with CRISPR-Cas13 we didn’t see any escaper mutants.”
Application of CRISPR/Cas9-Based Gene Editing in HIV-1/AIDS Therapy (2019):
https://t.co/OpFCn3uH1O
The safety and delivery efficiency of Cas9 also need consideration, since long term expression of Cas9/sgRNA may induce non-specific injury to the host genome and immune response.
CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape (2016):
https://t.co/y2GreH3EB2
DARPA Microphysiological Systems:
https://t.co/fNg9lUxfLc

U.S. Department of Defense:
https://t.co/oefauN4lz7
“The interactions that candidate 💊 and 💉 have with these mimics will accurately predict the safety and effectiveness the countermeasures would have if given to 👥.” https://t.co/io8sA205fD
A Crispr-Cas9 System Designed to Introduce Point Mutations into the Human ACE2 Gene to Weaken the Interaction of the ACE2 Receptor with the SARS-CoV-2 S Protein (May 2020):
https://t.co/JuarmcFR9u
https://t.co/HenCBrrRxD
Time - mRNA Technology Gave Us the First COVID-19 Injections (January 2021):
https://t.co/DELjdJGG1x
“CRISPR is also being used in the war against COVID. Doudna and others have created RNA-guided enzymes that can directly detect SARS-CoV-2 and eventually could be used to destroy”
NIH, Francis Collins, Dr. Fauci (March 2020):
'These are dramatic times for NIH research. Today, I focused on gene-based therapies. The CRISPR provides "find and replace" function for DNA.'

What are genome editing and CRISPR-Cas9?
https://t.co/vLihnXKvYn

https://t.co/psJ8lqzun4
Congressional Research Service - Advanced Gene Editing: CRISPR-Cas9 (December 2018):
https://t.co/27weYrBOSC
CRISPR-Cas9 to knock down microRNA in vitro and in vivo (2016):
https://t.co/PqCvspzGTK
"CRISPR-Cas9 can robustly and specifically reduce the expression of these microRNAs up to 96%"
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"the dysregulation of microRNAs has been associated with cancer"
https://t.co/y7QzTrZTO0
U.S. Military Preps for Gene Drives Run Amok (2016):
https://t.co/KgS7tqD6WR

Bill Gates - We Need to Embrace CRISPR Gene-Editing for Global Development (2018):
https://t.co/ihJOGAMt30

Bill Gates - How CRISPR could save lives and end diseases (2021):
https://t.co/okwuhoAo39
The Rockefeller University Hosts Panel On Human Genome Editing (2017):
https://t.co/Rct1VzeKdm

Dr. Matthew Liao, a bioethicist, suggests CRISPR for:
- cat eyes
- pharmacological induction of empathy
- hobbit people
- cognitive enhancement
- meat allergies
https://t.co/bddjG1a2W9
2020 Nobel Prize for Chemistry awarded for the development of a method for genome editing:
https://t.co/jF2EBz9OcU
Using CRISPR-Cas9 genetic scissors, researchers can change the DNA of animals, plants and microorganisms with extremely high precision - to rewrite the code of life.
Recent Advances in CRISPR/Cas9 Delivery Strategies (2020):
https://t.co/WuGrKXlowK
'The CRISPR/Cas9 system can be delivered in the format of DNA (“all-in-one” plasmid), mRNA (Cas9 mRNA and sgRNA), or protein (RNP).'
https://t.co/ujox6aqp9f
Modeling human disease in rodents by CRISPR/Cas9 genome editing (2017):
https://t.co/MKzpIOHrUX
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Self-destructing mosquitoes and sterilized rodents: the promise of gene drives (2019):
https://t.co/9pSCM9xnrB
https://t.co/LLTajEN2qP
Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging (2012):
https://t.co/aQQhz8oaDW
"Oxidative stress plays a critical role in cerebrovascular dysfunction induced by ACE2 deficiency and aging."
https://t.co/y7QzTrZTO0
mRNA-based therapeutics - a new class of drugs (2014):
https://t.co/r3HY2N37jE

Development of CRISPR-Cas9 mRNA for gene-editing (2013):
https://t.co/vFJfkbwCLT

"zebrafish has the same major organs and tissues as humans; ability to repair heart muscle"
https://t.co/9eqZpz1Rdy
Matthew Liao - Selecting Children: The Ethics of Reproductive Genetic Engineering (2008):
https://t.co/VvOTRqyDGa

Compulsory moral bioenhancement should be covert (August 2018):
https://t.co/giU0hN0uWR

H/t: @JesseMatchey, @maraki378
https://t.co/vBCv2eTjMq
George Church, Martin Nowak - Evolutionary dynamics of CRISPR-Cas9 gene drives (2016):
https://t.co/f4ITVRwUJy

Matthew Liao - Designing humans: A human rights approach (2018):
https://t.co/s14Ph02wRD
- 'Is Gene Editing Ethical? It Depends'

https://t.co/Fc1s6eBwLI
CRISPR-Cas9: Transhumanism and Designing the Living (2018):
https://t.co/1ulbtFfvdN

The Rockefeller Foundation - Bionics, Transhumanism, and the End of Evolution (2019):
https://t.co/yYS69gR1cC

"Jeffrey Epstein was a transhumanist."

H/t: @JesseMatchey
https://t.co/5uOJc0dBag
$21.9M Gene Modulation Research, Effort Targets Influenza Pandemics (June 2019):
https://t.co/CZumqc0OnO
"CDC will also partner with the team and will be funded separately by DARPA in this 4-year initiative."

Dr. Amy Jenkins - P3 & PREPARE DARPA Programs.
https://t.co/2PdksFhCER
Dr. Amy Jenkins Programs (DARPA, BTO):
- ADEPT
- INTERCEPT
- NOW
- P3
- PREPARE
- RPM
https://t.co/L5u6tTzeaY

Consultant to NIH's Somatic Cell Genome Editing Program – Phase 2 (FY23-27)
https://t.co/9LZVDiGQQg

NIH SCGE:
- https://t.co/ImLDVh5d6U
- https://t.co/5YbNvLLoNK
U.S. Army, Pfizer - COVID-19 Pandemic, Large Scale
Injections Manufacturing Demonstration (July 2020):
https://t.co/5CyLkTLEmL
"Pfizer has self-certified that it meets the
definition of a Nontraditional Defense Contractor as defined in the Base Agreement."
https://t.co/kiIQOqOBi4
What is the ACE2 receptor, how is it connected to coronavirus and why might it be key to treating COVID-19? (May 2020):
https://t.co/nSrQWtWOrE
“ACE2 is present in many cell types and tissues including the lungs, heart, blood vessels, kidneys, liver and gastrointestinal tract.” https://t.co/POJTwbpzcl
Albert Borula - WEF Agenda Contributor on “Future of Health and Healthcare”:
https://t.co/yIGrPiRm00

5 key trends for the future of healthcare (2018):
https://t.co/7dpo7CAgtr
- Gene Therapy
- Personalised medicine
- AI
- Wearables
https://t.co/70yqOzp7jR

H/t: @BFauker
Potential role of ACE2-related microRNAs in COVID-19's nephropathy (2020):
https://t.co/d0rdTOyM5D
"Based on this review, most of the ACE2-associated miRNAs affected multiorgans, therefore, their antimir therapy potentially lead to some adverse reactions."
https://t.co/tZxCQMZ4Yz
Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (April 2017):
https://t.co/SKLPDrdc3A
"Reduced expression of miR-132 by co-injection of
Cas9 mRNA and miR-132 gRNA."
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"miR-132 have relative evidence as ACE2 gene silencer."
https://t.co/4QAMzykDZb
NY Genome Center, NYU - CRISPR Screen Identifies Genes, Therapeutic Targets to Protect From Coronavirus Infection (October 2020):
https://t.co/KRxvc7Njok
"whether loss of some genes might confer resistance to the coronavirus by lowering ACE2 levels"
https://t.co/Cs6uwy8HfE
Transcriptional Inhibition of Host Viral Entry Proteins as a Therapeutic Strategy for SARS-CoV-2 (March 2020):
https://t.co/XkBFFdt4c1
https://t.co/Cs6uwy8HfE
A Guide to COVID-19 (May 23, 2020):
https://t.co/tREdKIsDQc
"authors were undergraduate students in a discovery-based research laboratory focused on projects centered on performing novel CRISPR-Cas9 genetic knockouts in zebrafish at Vanderbilt University"
https://t.co/LbfjcZsWck
PEG-GO, Poly(Ethylene Glycol) Functionalized Graphene Oxide, in Tissue Engineering: A Review on Recent Advances (April 2020):
https://t.co/5Vh1UL0b4F

https://t.co/0BkwNvzHwc
CRISPR 2.0: Base Editing (BE) in the Groove (March 2021):
"Researchers from the Broad Institute, the NIH, and Vanderbilt University have used an adenine base editor (ABE) to treat progeria in mice."
https://t.co/ZktPEIePjS

https://t.co/Mi0Q6e9cTw
Pfizer CRISPR-Cas9 mRNA:
1. mRNA for Adenine Base Editing
2. guideRNA (gRNA)
3. Amino lipid
4. Cholesterol
5. DSPC
6. Poly(Ethylene Glycol)-lipid
https://t.co/9HwX63Ud7A
"Moderna - Arbutus Biopharma LNP patent."
https://t.co/QNUKZ9oKNM

Arbutus Biopharma patents:
https://t.co/TAfaysB6kw
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Delivering CRISPR therapeutics with lipid nanoparticles (2015):
https://t.co/xAgR5rwNqn
"to silence the expression of the target gene"

https://t.co/yFPl8bfxZw

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Lu_lu\U0001f498
Lu_lu💘
@luciame16
Some thoughts on episode 53 of #Hercai

Love,that is not real,has no passion. Its fire turns into embers, it doesn’t not smell. The day, the night, the moon&year burn without sun, light, comfort&sleep.
Ömer Hayyam

#Reyyan #Miran #ReyMir #EbruŞahin #AkınAkınözü
#HercaiThoughts


1
PRAISE
The praise in this episode goes foremost to Ebru because she portrayed Reyyan so realistically like a woman who truly lost her unborn child. I was in awe and pain watching her along the episode, all her breakdowns and tears were so real.
#Hercai

2
Of course also Akın took his part and did his part masterfully, but he rightfully was the one who stood aside in this specific episode that needed to be about Reyyan’s pain and thus concentrated on Ebru.
#Hercai

3
And last but not least, if I say thank you to something that B gave us this year, then it’s to have Ali as our director. Also in this episode we saw the artistic eye behind every shot and I loved it.
#Hercai

4
OVERALL COMMENT
I don’t know who wrote ep. 52 but ep. 53 was going strong once more on symbols: roses, stones, fire and trees were incorporated and especially the ReyMir dialogues were written very well. I truly loved every ReyMir scene.
So let's get into it.
#Hercai
CULTURE
Techno Funda Investing
Techno Funda Investing
@TechnoFunda6
Thread 🧵explaining #ROE & #ROCE and its use in #FundamentalAnalysis

(Must read for #FA learners)

🙏Like & RT to spread learning with all 🙏

Views Welcome 👉 @dmuthuk @Vivek_Investor @datta_arvind @caniravkaria @FI_InvestIndia @AdityaD_Shah

#FundamentalAnalysis #StockMarket


1⃣

Return on Equity (#ROE) and Return on Capital Employed (#ROCE) are two important Financial Ratios used in #FundamentalAnalysis of Stocks.

#StockMarket #Investing

2⃣

Return on Equity (ROE) is the ratio of Net Income (Net Profit) of a company and it’s Total Equity (Shareholder's Equity).

Here - Shareholders Equity = Share Capital + Reserves & Surplus.

#StockMarket #Investing #FundamentalAnalysis


3⃣

#ROE is a measure of how much net profit a company is making for every rupee invested by its shareholders in the company.

It can be said that higher the ROE, better it is for the equity shareholders. It tells shareholders about how effectively their money is being used.

4⃣

However, you should not trust high ROE blindly. Biggest drawbacks or weaknesses of ROE is that it completely ignores debt.

Hence for companies having high levels of debt, ROE will give a higher but misleading value & therefore we need to look at #ROCE along with #ROE.
ACCOUNTING , FUNDAMENTAL ANALYSIS , ROE VS ROCE ANALYSIS
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\uff2c\uff41\uff44\uff59 \uff22\uff4c\uff41\uff5a\uff45\uff53
Ｌａｄｙ Ｂｌａｚｅｓ...
@Lady_Blazes
Oh my Goodness!!!

I might have a panic attack due to excitement!!

Read this thread to the end...I just had an epiphany and my mind is blown. Actually, more than blown. More like OBLITERATED! This is the thing! This is the thing that will blow the entire thing out of the water!


Has this man been concealing his true identity?

Is this man a supposed 'dead' Seal Team Six soldier?

Witness protection to be kept safe until the right moment when all will be revealed?!

Who ELSE is alive that may have faked their death/gone into witness protection?


Were "golden tickets" inside the envelopes??


Are these "golden tickets" going to lead to their ultimate undoing?

Review crumbs on the board re: 'gold'.


#SEALTeam6 Trump re-tweeted this.
GOVERNMENT
Khatvaanga
Khatvaanga
@khatvaanga
Sri Gurubhyo Namah.
Some tweets on Adi Shankaracharya and in particular the Guru Parampara of @sringerimath. [I had done this series earlier 5 years ago on account of Shishya Sweekaram].


Adi Shankara established the Sringeri Peetham as the 1st of 4 amnaaya peetams.

The four being
1. Sarada Peetam at Sringeri.
2. Govardhana Peetam at Puri
3. Kalika at Dwaraka
4. Jyothir at Badarikashramam.

He installed his 4 most prominent shishyas as heads of the peetams.

Sureshwaracharya was assigned to Sringeri as its head.

Sringeri is a corruption of Rshyashrunga giri.

Rshyashrunga maharshi [and his father Sri Vibandhaka Maharshi] did their tapas at this place.

It is at Sringeri that Shankara spent 12 of His precious 32 years!!

That gives you and idea how much He loved this place.

Rshyashruga maharshi had a horn on his forehead, a result of being born to a deer. His mere presence was enough to shower rains!!

Rshyashrunga was one who led Putrakamesthi Yaagam of Dasaratha Maharaj and which resulted in Sri Rama's birth!!
ALL
Sara Benincasa
Sara Benincasa
@SaraJBenincasa
Spent a quaint half hour in a cafe listening to a guy yell at his dad after his dad said that the women Trump molested wanted it: "Dad, that's like saying the Jews who died in the Holocaust were asking for it!" ENJOY YOUR TERRIBLE FAMILIES THIS WEEK!

"Mom, has a man ever touched you without your consent?"
"Of course."
"Did you report it?"
"No."
"Dad, your WIFE has been through this!"

Dad was unmoved and told the guy to stop arguing with him.

At this point we learned the boy child has allergies.

I forgot to remark upon the presence of the very cute grandson, who was very small and gave not one shit about the yelling. I believe a sister or aunt was present and feeling very stressed. I wanted to hand her a Xanax or seven.

It was really hard to not jump in and say, "Sounds like you guys are going to have a fun meal tomorrow!" so they could unite in hatred against me, the outsider, and stop squabbling. Instead I exchanged glances with a nearby fellow lady patron, who also emotionally ate a cookie.

Anyway, I want to thank the random family for yelling about rape and the Holocaust in an Israeli cafe in the US of A today because it reminded me that while this country isn't the greatest, it is inevitably my stupid favorite and I am never, ever bored.
SOCIETY