This is why I'm not a critic of "cancel culture." It's crucial to impose social costs for the breech of key social norms. The lesson of overreaction is that we need to recalibrate judgment to get it right next time, not that we need a lot more bad judgment in the other direction.
Every single critic of "cancel culture" just thinks the wrong people are getting canceled. pic.twitter.com/DDIVccj8zV
— Michael Hobbes (@RottenInDenmark) February 2, 2021
More from Twitter
Inside: Dependency Confusion; Adam Curtis on criti-hype; Catalytic converter theft; Apple puts North Dakota on blast; and more!
Archived at: https://t.co/Osts9lAjPo
#Pluralistic
1/

This weekend, I'll be participating in Boskone 58, Boston's annual sf convention, where I'm doing panels and a reading.
https://t.co/2LfFssVcZQ
2/

Dependency Confusion: A completely wild supply-chain hack.
https://t.co/TDRNHUX0Ug
3/

In "Dependency Confusion," security researcher @alxbrsn describes how he made a fortune in bug bounties by exploiting a new supply-chain attack he calls "dependency confusion," which allowed him to compromise "Apple, Microsoft and dozens of others."https://t.co/hn32EmF5qT
— Cory Doctorow #BLM (@doctorow) February 10, 2021
1/ pic.twitter.com/eqFr3GXlyX
Adam Curtis on criti-hype: Big Tech as an epiphenomenon of sociopathic mediocrity, not supergenius.
https://t.co/MYmHOosTk3
4/

Adam Curtis is a brilliant documentarian, and films like Hypernormalization and series like All Watched Over by Machines of Loving Grace had a profound effect on my thinking about politics, technology and human thriving.
— Cory Doctorow #BLM (@doctorow) February 11, 2021
1/ pic.twitter.com/gydJK358BX
Catalytic converter theft: Rhodium at $21,900/oz.
https://t.co/SDMAXrQwdd
5/

Back in the early 2010s, people started falling into open sewer entrances in New York City and other large metros - because a China-driven spike in the price of scrap metal, combined with post-2008 unemployment, gave rise to an army of metal-thieves.https://t.co/gtD72IDCPn
— Cory Doctorow #BLM (@doctorow) February 11, 2021
1/ pic.twitter.com/gdgVJoMoY8
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Week 1 highlights: getting shortlisted for YC W2019🤞, acquiring a premium domain💰, meeting Substack's @hamishmckenzie and Stripe CEO @patrickc 🤩
2/ So what is Brew?
brew / bru : / to make (beer, coffee etc.) / verb: begin to develop 🌱
A place for you to enjoy premium content while supporting your favorite creators. Sort of like a ‘Consumer-facing Patreon’ cc @jackconte
(we’re still working on the pitch)
3/ So, why be so transparent? Two words: launch strategy.
jk 😅 a) I loooove doing something consistently for a long period of time b) limited downside and infinite upside (feedback, accountability, reach).
cc @altimor, @pmarca

4/ https://t.co/GOQJ7LjQ2t domain 🍻
It started with a cold email. Guess what? He was using BuyMeACoffee on his blog, and was excited to hear about what we're building next. Within 2w, we signed the deal at @Escrowcom's SF office. You’re a pleasure to work with @MichaelCyger!
5/ @ycombinator's invite for the in-person interview arrived that evening. Quite a day!
Thanks @patio11 for the thoughtful feedback on our YC application, and @gabhubert for your directions on positioning the product — set the tone for our pitch!

@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj

@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
