'Stay at home' for #LekkiMassacre protest is not a sign of weakness. The likes of Odanz -or is it Odense? - have called attention to this and they are not pacifists. They are strategist-realists.
Activism is the art of war. Pounce when the enemy is at its weakest [Thread]

I think the UK trans debate has teased out the sticking points for feminists, and it might be useful to lay them out given that the battle in the US, with a very different legislative environment, is just starting.

The GRA of 2004 gave trans people the ability to change legal sex via a GRC, but only if they had a psychiatric diagnosis of dysphoria and only after having lived in role for 2 years. The spousal veto gave spouses a chance to annul or obtain a favourable divorce.

While this ultimately created the loophole in women's rights that we've been fighting against in the last few years, it catered for a tiny number of dysphoric transsexuals and so did not have an enormous impact.

Discussions with trans friends and allies make it clear that, although surgery wasn't a requirement for a GRC, the diagnostic procedures were expected to trap and exclude males who did not want surgery, thereby preventing fetishists and opportunists from exploiting a GRC.

The Equality Act of 2010 defined the various protected characteristics, including both sex and 'gender reassignment', and provided for sex-based exemptions, under the auspices of which it is legal to exclude trans people from some single-sex spaces and services.

1/ Something strange is happening with people’s sex lives. 20-somethings are having sex later and less frequently than previous generations. I spent several months digging into this for @theatlantic. https://t.co/5ehzmWY9wi

2/ This phenomenon—I’m calling it a Sex Recession—really surprised me. It seemed improbable in the age of Tinder, digital porn, and attitudes that are generally permissive and sex-positive.

3/ What’s happening isn’t exclusively American: Similar trends are being observed in other countries, including Japan, Australia, the U.K., Finland, and the Netherlands.

4/ One cause is obvious: Adults under 35 are less likely to be living with a partner than in recent decades, and more likely to be living with their parents—which, it’s safe to say, isn’t great for one’s sex life.

5/ But I also found other explanations, each with profound implications. The first, unsurprisingly, has to do with internet enticements. Netflix and other online entertainment may be substituting for sex.

OK winger wonderland story time boys & girls.

1. Sleet stops, it's warming up, neighbor decides get out & drive, probably after seeing some truck drive down our residential road (4-wheel drive). Neighbor has new SUV push button start, 2-wheel drive, which is NOT THE SAME THING.

2. So anyway, they back out of their garage & then pull forward down their driveway. The driveway is flat, but it's also a really really long driveway that goes from the back of the house down the side of the house. This will be important later.

3. They make it down the driveway just fine, so now super confident this will go well.

They pull out on our little residential road and start driving.

Mother nature is laughing her ass off right about now.

4. I should mention the roads through our little subdivision don't have curbs or sewers. We're basically out in the country so they just slope roads so the run-off goes into a ditch at the side of the road.

5. So anyways, their SUV starts to slightly fishtail. They haven't gone far at this point. So, they stop, and the SUV, although stopped, just ever so slowly slides to the side of the road and ends up half way in the ditch & almost tipped over.

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10