- The NK cell proliferation ability declines with age: older people have a decreased ability to produce NC cells rapidly: https://t.co/VZ9PSW5OBU
(1/n) The important role of natural killer (NK) cells in COVID-19.
A summary of key insights:
- NK cells are cytotoxic lymphocytes & part of the innate immune system
- They play an important role in virus infection control & immunomodulation
- The NK cell proliferation ability declines with age: older people have a decreased ability to produce NC cells rapidly: https://t.co/VZ9PSW5OBU
- As early as June 2020, it was hypothesised that NCCs could be key in explaining severe COVID-19 courses: https://t.co/yJPXeXcku0
- Indeed, it was later found that NK cells from COVID-19 patients do not function well:https://t.co/aEK9KpaA45
- The activity of NK cells is downregulated by the cytokine transforming growth factor-β (TGFβ)
- Blood serum of patients with severe COVID-19 inhibits NK cell function in a TGFβ-dependent manner: https://t.co/aEK9KpaA45
- An untimely early production of TGFβ and associated NK cell dysfunction is a hallmark of severe COVID-19
- The inhibition of untimely TGFβ production & the promotion of NK cell function may positively affect SARS-CoV-2 control on multiple levels: https://t.co/zjeCnASWhx
- A lower NK cell count in COVID-19 patients has been shown to be correlated with a lower survival rate:https://t.co/EUQkL76GhW
- NK cell dysregulation as a key factor in COVID-19 was also highlighted 1.5 years ago: https://t.co/Dg0KmYT2iS
- “Restoration of NK cell effector functions has the potential to correct the delicate immune balance required to effectively overcome SARS-CoV-2 infection.”
- Vitamin D (our old friend!) also plays a role for the NK cells. Vitamin D deficiency correlates with a reduced number of NK cells in COVID-19 patients: https://t.co/YNrvKIrlgj
- While early NK cell stimulation & IFN-γ production is beneficial to combat infections, excessive & prolonged stimulation of NK cells leads to reduced NK cell numbers & an exhausted phenotype associated with increased systemic inflammation:
https://t.co/vPpfKbntne
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Fake chats claiming to be from the Irish African community are being disseminated by the far right in order to suggest that violence is imminent from #BLM supporters. This is straight out of the QAnon and Proud Boys playbook. Spread the word. Protest safely. #georgenkencho
There is co-ordination across the far right in Ireland now to stir both left and right in the hopes of creating a race war. Think critically! Fascists see the tragic killing of #georgenkencho, the grief of his community and pending investigation as a flashpoint for action.
Across Telegram, Twitter and Facebook disinformation is being peddled on the back of these tragic events. From false photographs to the tactics ofwhite supremacy, the far right is clumsily trying to drive hate against minority groups and figureheads.
Declan Ganley’s Burkean group and the incel wing of National Party (Gearóid Murphy, Mick O’Keeffe & Co.) as well as all the usuals are concerted in their efforts to demonstrate their white supremacist cred. The quiet parts are today being said out loud.
The best thing you can do is challenge disinformation and report posts where engagement isn’t appropriate. Many of these are blatantly racist posts designed to drive recruitment to NP and other Nationalist groups. By all means protest but stay safe.
There is co-ordination across the far right in Ireland now to stir both left and right in the hopes of creating a race war. Think critically! Fascists see the tragic killing of #georgenkencho, the grief of his community and pending investigation as a flashpoint for action.
Across Telegram, Twitter and Facebook disinformation is being peddled on the back of these tragic events. From false photographs to the tactics ofwhite supremacy, the far right is clumsily trying to drive hate against minority groups and figureheads.
Be aware, the images the #farright are sharing in the hopes of starting a race war, are not of the SPAR employee that was punched. They\u2019re older photos of a Everton fan. Be aware of the information you\u2019re sharing and that it may be false. Always #factcheck #GeorgeNkencho pic.twitter.com/4c9w4CMk5h
— antifa.drone (@antifa_drone) December 31, 2020
Declan Ganley’s Burkean group and the incel wing of National Party (Gearóid Murphy, Mick O’Keeffe & Co.) as well as all the usuals are concerted in their efforts to demonstrate their white supremacist cred. The quiet parts are today being said out loud.
There is a concerted effort in far-right Telegram groups to try and incite violence on street by targetting people for racist online abuse following the killing of George Nkencho
— Mark Malone (@soundmigration) January 1, 2021
This follows on and is part of a misinformation campaign to polarise communities at this time.
The best thing you can do is challenge disinformation and report posts where engagement isn’t appropriate. Many of these are blatantly racist posts designed to drive recruitment to NP and other Nationalist groups. By all means protest but stay safe.
