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This is a must-read article by @mlipsitch and @kesvelt and I strongly agree with the central points: we urgently need to step up genomic surveillance & get transmission down now in the US while these are rare.

But a couple things to expand on from a virology point of view.


The piece talks about the B117 variant as if it’s not SARS-CoV-2, but it is. B117 is distinguished by 23 changes across the genome, but it’s still fundamentally the same virus. It’s a different variant (some are calling it a strain depending on how that’s defined).

But 23 nucleotide changes aren’t sufficient to make this a completely different virus. So we are still fighting SARS-CoV-2. Just a new and improved version. Improved how? Well it’s more transmissible but the mechanism isn’t yet known.

When viruses become more transmissible it can happen in a few different ways:
-virus can be more fit (replicate to higher titers, hence more shedding)
-virus can replicate more efficiently in specific tissues (like the nose)
-spike can bind the receptor more efficiently and...

...thus infect host cells more efficiently
-virus can get better at evading/antagonizing innate host antiviral defenses
-increased environmental stability
-people can shed virus for longer periods of time
Sharing.


“What authority does POTUS have specifically over the Marines?”

“only branch of service that falls directly under exec command”

“Nati Sec Act of 1947, amended in 1952, specifies the duties of the USMC to include: ‘perform such other duties as the president may direct.’”


This is the QProof. Go back


10/31/2017, Q wrote:

“Why is ANTIFA allowed to operate?
Why hasn't the MB been classified as a terrorist org?
What happens if Soros funded operations get violent and engage in domestic terrorism?
What happens if mayors/ police comms/chiefs do not enforce the law?”

2020...


How is it possible?
The NRA is already trying to juice gun sales by creating fear around a new Biden administration. “Stay vigilant and engaged” sounds a lot like “shoot people who disagree with you” to their supporters - too many of whom have been radicalized by the gun lobby’s extremist agenda.


This NRA owns much of blame for the armed white supremacists trying to undermine American democracy: “The gun-rights movement cleared the path for insurrection. It blew a hole in the rule of law—and Donald Trump’s would-be soldiers clamored through it.”

Many members of the mob that rioted inside the Capitol lead or belong to so-called “gun-rights groups,” and were motivated by the warnings of tyranny issued by the @NRA.

Guns are an integral part of anti-government and white supremacist violence. In 2017, a joint report from the FBI and DHS said “firearms likely will continue to pose the greatest threat of lethal violence by [extremists] due to their availability and ease of use.”

Here’s an example. In October 2018, Donald Trump claimed a “caravan” of migrants was heading to the US from Mexico. NRATV, then the propaganda arm of the NRA, claimed Jewish billionaire George Soros was conspiring with Venezuela to send migrants here to influence the election.