By flushing out the same inflammation that leads to depletion of the tryptophan pathway (which adjacently leads to depletion of serotonin) by all tryptophan depleting down to NAD+ in response to inflammation, niacin will quickly restore serotonin by restoring tryptophan.

@freedom9230 It’s not really “excess” serotonin produced but rather, previously depleting/deficient serotonin becoming rapidly restored once the inflammation that was depleting it is flushed out by niacin.
@freedom9230 Once inflammation is for the most part flushed out and thermodynamic energy transfer / metabolism / all auxiliary biochemistry are restored to more homeostatic states, supplemented niacin won’t affect tryptophan down to NAD+ or tryptophan to serotonin pathways.
@freedom9230 Instead, with continued dosing, sufficiently supplied niacin will then work as continued pump-action against any downstream inflammation / free radical electrons that manifest thereafter by turning into NAADP if needed... and any free intracellular niacin will be urinated out
@freedom9230 Does that make sense? Lol
@freedom9230 And note: I have come across a few individuals who experience this rapid-restoration of serotonin (and other neurotransmitters) that they’ve never felt before - this marked relative difference in how little serotonin they had now being restored fully at such a rapid pace
@freedom9230 Often this is mistakenly confused with an allergic reaction (it's not) or that these individuals can't handle niacin, thinking it's leading to this massive serotonin overload. In reality, it's just the experience of this relative marked difference between how little serotonin...
@freedom9230 ... they had as a result of it depleting b/c of ensuing inflammation versus its rapid restoration with sufficient niacin supply. Smaller doses can ease this sudden change (but you still want to make sure it's sufficient niacin to induce flush)..
@freedom9230 ... and very quickly with subsequent continued dosing, the serotonin won't need to restore (and certainly won't need to as rapidly as with the first flush), so those unwanted sensations of rapid serotonin restoration won't occur anymore as serotonin will be restored.
@freedom9230 And as noted, continue niacin dosing beyond the doses that flushed out most of this inflammation that was ensuing before niacin dosing, by shielding against further inflammation, will prevent depletion of serotonin (& keep it sufficient) among other compounds/biochemical pathways
@freedom9230 Some more...

More from For later read

I’ve been frustrated by the tweets I’ve seen of this as a Canadian. Because the facts are being misrepresented.

We’re not under some sort of major persecution. That’s not what this is. A thread. 1/8


This church was fined for breaking health orders in Dec. They continued to break them. So the pastor was arrested and released on conditions of... you guessed it, not breaking health orders. And then they broke the health orders. 2/8

So then he was arrested and told he couldn’t hold church services in person if he was to be released. He refused. He’s still in custody.

Here is my frustration as a Christian in Canada:

1. They were able to gather, with some conditions. They didn’t like those. 3/8

2. He is not actually unable to preach. He is just unable to hold church services because they broke the conditions given by the public health office in Alberta. He says he can’t in good conscience do that, so they are keeping him in jail (because he will break the law). 4/8

3. This is the 1st article of The Canadian Charter of Rights and Freedoms: “guarantees the rights and freedoms set out in it subject only to such reasonable limits prescribed by law as can be demonstrably justified in a free and democratic society.” 5/8
I’ve asked Byers to clarify, but as I read this tweet, it seems that Bret Stephens included an unredacted use of the n-word in his column this week to make a point, and the column got spiked—maybe as a result?


Four times. The column used the n-word (in the context of a quote) four times. https://t.co/14vPhQZktB


For context: In 2019, a Times reporter was reprimanded for several incidents of racial insensitivity on a trip with high school students, including one in which he used the n-word in a discussion of racial slurs.

That incident became public late last month, and late last week, after 150 Times employees complained about how it had been handled, the reporter in question resigned.

In the course of all that, the Times' executive editor said that the paper does not "tolerate racist language regardless of intent.” This was the quote that Bret Stephens was pushing back against in his column. (Which, again, was deep-sixed by the paper.)

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