BC DRUG
Saved by @Alex1Powell

Moderna data has arrived at the FDA.... I'll be tweeting about the 54-page document by the FDA https://t.co/rh3K9BvqgO The brief from Moderna is much smaller than BNT/Pfizer's - only 84 pages (+ a 7-page presentation) https://t.co/EWDYzYwf2g 1/n

 ..Efficacy data is for 27,817 people randomized to either vaccine or placebo; & there's safety data for 30,350 people. I'll get started with the adverse events data, because that has been a question mark for this vaccine...2/n
...The FDA raises lymphadenopathy & Bell's palsy again. More people with lymphadenopathy with Moderna's vaccine than BNT/Pfizer's: 173 in vaccine group, 95 in placebo. Bell's palsy similar. Frequency of serious adverse events (SAEs) low: 1.0% in vaccine & placebo arms...3/n
...FDA expressed no concern about any SAE: 7 SAEs were determined by FDA to be vaccine-related or potentially so (more than the sponsor deemed related) - several from nausea/vomiting. People died at the same rate as would expected for their age groups, the FDA concluded...4/n
...A developmental/reproductive toxicity study report was included: FDA identified no serious concern about adverse impact on pregnancy or perinatal/postnatal development. All up, no safety concern that would prevent emergency authorization... 5/n
Solicited adverse events (AEs) in 1st 7 days were considerably more common than for BNT/Pfizer vaccine - close to universal: 92% had local reactions, 83% systemic - severe systemic reactions were common: 17%.(Remember: BNT/Pfizer has a 30μg dose; Moderna 100μg.) ...6/n
... Frustratingly, solicited AEs are only reported here split into people under & over 65, & differently in general to the BNT/Pfizer report. So can't unpack this quickly...7/n
...Eg fatigue. After 2nd dose, was 68% for 18-64 year-olds; 58% for 65+. Severe fatigue: 11% for younger, 7% for 65+.

For BNT/Pfizer, it was 59% overall, severe was 5%. But the 2 trials have different age spread, for example. Complicated...8/n
...Bottom line, many similarities, but some types of AEs tilt to more common & severe for Moderna; some other things seem more clear, tho depends how measured etc: eg rate of pain around the injection site is higher (80-90%, severe 5% & 3%; for BNT/Pfizer, 66%, severe 0.5%)..9/n
...OK, over to the efficacy questions. Overall efficacy, after 2 doses & a week (people with no previous SARS-Cov-2 infection): that's the great news we already knew - 95% efficacy overall... 10/n
...Vaccine efficacy was similarly high for people with co-morbidities at high risk for severe Covid-19 (remembering some, as for all these trials, were excluded). 0 people out of 13,934 in this efficacy analysis got severe Covid-19 vs 11 in the placebo group. ...11/n
... There was 1 person (⬇️) in the vaccine group who was severely ill, but without a confirmed test result till later - so the 0 severe Covid-19 call is questionable here. (So no major difference here between the 2 vaccines) ...12/n
...Here's the corresponding incidence graph to the now-famous one for BNT/Pfizer. However, there wasn't a calculation for vaccine efficacy after 1 or 2 shots, to see if the extra week between shots makes a difference (BNT/Pfizer has 3-wk interval, Moderna 4)...13/n
..Finally, news on efficacy & age is great: similar for both vaccines. Some differences as numbers are smaller for Moderna (& there's 0 Covid-19 for 65+, while BNT/Pfizer had 1 in a larger group). But basically, great news - though one seems somewhat easier to tolerate...14/ fin
Not "fin" after all! Firstly @Nutmeg031992 pointed out my screenshot was for the interim efficacy analysis. Apologies! Here's the final vaccine efficacy: 15/16
Vaccine efficacy for both vaccines was similar for Hispanic/Latino & Black/African-American groups to overall. (BNT/Pfizer had a much larger number of Hispanic/Latino people.) ... 16/16
I checked the sponsors' document https://t.co/EWDYzYwf2g but couldn't find the modified intention-to-treat vaccine efficacy I was hoping for (1 or 2 shots, with/without previous infection). However, there was this good overview. .../ends (really!)

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We rightfully complain that marginalized people are not allowed to be fully human.

But we internalize and transfer our oppression daily. It’s a smog. We all breathe it in & act it out.

And then tell WoC “girl ain’t you supposed to be a _______? Why you doing ____?”

Can I live?

And don’t go reading anything personal into this-this isn’t about me necessarily and it’s no subtweet (I try hard not to do that.)

I’ve just been observing that behavior more and more lately. Especially when it comes to marginalized folks.

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“Can’t knock the hustle” should be our anthem.

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On Sunday 21st June, 14 year old Noah Donohoe left his home to meet his friends at Cave Hill Belfast to study for school. #RememberMyNoah💙


He was on his black Apollo mountain bike, fully dressed, wearing a helmet and carrying a backpack containing his laptop and 2 books with his name on them. He also had his mobile phone with him.

On the 27th of June. Noah's naked body was sadly discovered 950m inside a storm drain, between access points. This storm drain was accessible through an area completely unfamiliar to him, behind houses at Northwood Road. https://t.co/bpz3Rmc0wq


"Noah's body was found by specially trained police officers between two drain access points within a section of the tunnel running under the Translink access road," said Mr McCrisken."

Noah's bike was also found near a house, behind a car, in the same area. It had been there for more than 24 hours before a member of public who lived in the street said she read reports of a missing child and checked the bike and phoned the police.
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This isn't actually right, so here is another suggestion.

2/ I remember being 26 and writing about reading 52 books a year. I wrote blog posts about it. They got copied. It became "a thing." Now it's in Twitter bios. It looks impressive but it's insanely useless and I shouldn't have done it.

3/ what I should have known at that time is that only young idiots like myself, with no accomplishments, find list of tiny achievements impressive. Anyone who has actually done anything of substance doesn't gaf

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