In this thread @EricTopol describes evidence from Israel of waning anti-#SARSCoV2 immunity months after mRNA #COVID19 #vaccination.
But as I wrote https://t.co/NZk0v3r6Dc the explanation is about timing. People ARE immune, but after months response goes
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Bullshit.
I have family members all the way up the Fox News Facebook misinformation hole, and they didn’t get vaccinated because they felt respected; they got vaccinated because their children told them they wouldn’t get to see their grandchildren until they got vaccinated.
3 observations:
People don't tend to change their worldviews from a place of comfort.
When selfish assholes decide to behave like selfish assholes, the problem isn't that others aren't coddling their feelings enough.
Selfish assholes aren't everyone else's job to fix.
Selfish assholes would love for you to *think* they are everybody else's job to fix.
It puts them at the center and in control.
That means when they act like a selfish asshole, it's *your* fault. You should have been more persuasive. Daddy hits you because you made him angry.
Truth is, vaccine resistors are behaving this way because their feelings ARE being respected.
Malicious media entities created self-feeding networks that reassure selfish assholes they can be selfish assholes and still be respected.
Antvax, racist, sexist, all are welcome.
The way you make a selfish asshole stop being a selfish asshole is well known.
You draw a clear boundary and then you enforce that boundary. You tell them that their bullshit won't be tolerated, and then you don't tolerate their bullshit.
I think we all know that, actually.
I have family members all the way up the Fox News Facebook misinformation hole, and they didn’t get vaccinated because they felt respected; they got vaccinated because their children told them they wouldn’t get to see their grandchildren until they got vaccinated.
Vaccine resisters can\u2019t be persuaded if they feel disrespected | Opinion by @michaelbd https://t.co/nwszm47IOf
— National Review (@NRO) July 16, 2021
3 observations:
People don't tend to change their worldviews from a place of comfort.
When selfish assholes decide to behave like selfish assholes, the problem isn't that others aren't coddling their feelings enough.
Selfish assholes aren't everyone else's job to fix.
Selfish assholes would love for you to *think* they are everybody else's job to fix.
It puts them at the center and in control.
That means when they act like a selfish asshole, it's *your* fault. You should have been more persuasive. Daddy hits you because you made him angry.
Truth is, vaccine resistors are behaving this way because their feelings ARE being respected.
Malicious media entities created self-feeding networks that reassure selfish assholes they can be selfish assholes and still be respected.
Antvax, racist, sexist, all are welcome.
The way you make a selfish asshole stop being a selfish asshole is well known.
You draw a clear boundary and then you enforce that boundary. You tell them that their bullshit won't be tolerated, and then you don't tolerate their bullshit.
I think we all know that, actually.
Breaking—UK scientists just reported a case-control study that the mutated UK 🇬🇧B.1.1.7 variant is not associated w/ more severe #COVID19— “found no significant differences in hospital admissions and case fatality at 28 days, & occurrence of reinfections”, says @mvankerkhove
2) That said, the new UK mutated strain is a more transmissible (contagious) variant. Keep transmissibility and illness severity separate. They are two different things. Don’t get them confused.
3) The new UK variant severity study is included in today’s WHO report, to be released soon this afternoon according to WHO sources. Waiting for it to drop. I’ll keep folks posted on the details.
4) Update: here is UK Technical report on #SARSCoV2 variant of concern (B.1.1.7) in 🇬🇧 with prelim findings from their case-control study of no increased severity for the new variant that I reported yesterday.
5) Also keep in a mind that a virus that spreads faster (more contagious) yields much worse total outcomes than a virus that is just merely more severe.
All things equal, a new mutated variant that is more contagious & no more severe is worse. And that is what we now have.
2) That said, the new UK mutated strain is a more transmissible (contagious) variant. Keep transmissibility and illness severity separate. They are two different things. Don’t get them confused.
3) The new UK variant severity study is included in today’s WHO report, to be released soon this afternoon according to WHO sources. Waiting for it to drop. I’ll keep folks posted on the details.
4) Update: here is UK Technical report on #SARSCoV2 variant of concern (B.1.1.7) in 🇬🇧 with prelim findings from their case-control study of no increased severity for the new variant that I reported yesterday.
5) Also keep in a mind that a virus that spreads faster (more contagious) yields much worse total outcomes than a virus that is just merely more severe.
All things equal, a new mutated variant that is more contagious & no more severe is worse. And that is what we now have.
Why a SARS-CoV-2 variant that's 50% more transmissible would in general be a much bigger problem than a variant that's 50% more deadly. A short thread... 1/
— Adam Kucharski (@AdamJKucharski) December 28, 2020
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
So the cryptocurrency industry has basically two products, one which is relatively benign and doesn't have product market fit, and one which is malignant and does. The industry has a weird superposition of understanding this fact and (strategically?) not understanding it.
The benign product is sovereign programmable money, which is historically a niche interest of folks with a relatively clustered set of beliefs about the state, the literary merit of Snow Crash, and the utility of gold to the modern economy.
This product has narrow appeal and, accordingly, is worth about as much as everything else on a 486 sitting in someone's basement is worth.
The other product is investment scams, which have approximately the best product market fit of anything produced by humans. In no age, in no country, in no city, at no level of sophistication do people consistently say "Actually I would prefer not to get money for nothing."
This product needs the exchanges like they need oxygen, because the value of it is directly tied to having payment rails to move real currency into the ecosystem and some jurisdictional and regulatory legerdemain to stay one step ahead of the banhammer.
If everyone was holding bitcoin on the old x86 in their parents basement, we would be finding a price bottom. The problem is the risk is all pooled at a few brokerages and a network of rotten exchanges with counter party risk that makes AIG circa 2008 look like a good credit.
— Greg Wester (@gwestr) November 25, 2018
The benign product is sovereign programmable money, which is historically a niche interest of folks with a relatively clustered set of beliefs about the state, the literary merit of Snow Crash, and the utility of gold to the modern economy.
This product has narrow appeal and, accordingly, is worth about as much as everything else on a 486 sitting in someone's basement is worth.
The other product is investment scams, which have approximately the best product market fit of anything produced by humans. In no age, in no country, in no city, at no level of sophistication do people consistently say "Actually I would prefer not to get money for nothing."
This product needs the exchanges like they need oxygen, because the value of it is directly tied to having payment rails to move real currency into the ecosystem and some jurisdictional and regulatory legerdemain to stay one step ahead of the banhammer.