CV: https://t.co/fXlqRIJoWO
Let's say the WIV did not have yeast artificial cromosomes yet, they would have had to rely on bacteria as described here:
https://t.co/F4C9HfVcXv
2/x
How SARS2 was stitched together
Nowadays,SARS2 like viruses can be generated in lab within weeks https://t.co/uWAI0oMrIU
If this was possible in Wuhan 2018/19 is debatable.
However, Shi Zhengli had 2 grants to investigate which manipulations enable bat viruses to go pandemic.
1/x
CV: https://t.co/fXlqRIJoWO
Let's say the WIV did not have yeast artificial cromosomes yet, they would have had to rely on bacteria as described here:
https://t.co/F4C9HfVcXv
2/x
https://t.co/Qi180L3c9u
In either case, one would need a special kind of Type IIS endonucleases (DNA cleaving enzymes):
3/x
4/x
All these parameters, that do not have any advantage in natural evolution, are miraculously also met by SARS2.
This backbone also enables super easy RBM/FCS manipulations.
5/x
Such variants of RaTG13 could be produced for a few $100.
6/x
The restriction sites are much less irregular, the first fragment would have probably been to big (10.4kb)
Some sites were re-used (doesn't alter the protein sequence), others newly removed/introduced.
smoking gun#4?
7/7
yes, this is no ultimate proof that SARS2 was build in a lab.
It's yet another BIG smoking gun inconsistant with natural evolution.
I picked a provokative title as virologists seem to be ok with condemning origin theories in @Nature with zero evidence these days.
wow, this has gone viral🙃.
I do not want to tell anybody how to interpret this.
Still, few personal notes:
-none of this indicates SARS2 was build as a weapon
-the aim of the project may have been understanding pandemics
-warnings were ignored & safety abysmal (BSL2)
-it has seen a boom since the pandemic
-it is done mostly unregistered, unregulated and under inappropriate safety conditions
-this mess could be much worse if the technology got into the hands of terrorists
😱
https://t.co/efJe7adVFX
So, in silico, WIV would never make:
— Francisco de Asis (@franciscodeasis) April 16, 2021
- non-synonymous mutations
- splicing within genes
But they could make:
- synonymous mutations
- swap genes or the complete genome from other real viruses
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THREAD: 12 Things Everyone Should Know About IQ
1. IQ is one of the most heritable psychological traits – that is, individual differences in IQ are strongly associated with individual differences in genes (at least in fairly typical modern environments). https://t.co/3XxzW9bxLE
2. The heritability of IQ *increases* from childhood to adulthood. Meanwhile, the effect of the shared environment largely fades away. In other words, when it comes to IQ, nature becomes more important as we get older, nurture less. https://t.co/UqtS1lpw3n
3. IQ scores have been increasing for the last century or so, a phenomenon known as the Flynn effect. https://t.co/sCZvCst3hw (N ≈ 4 million)
(Note that the Flynn effect shows that IQ isn't 100% genetic; it doesn't show that it's 100% environmental.)
4. IQ predicts many important real world outcomes.
For example, though far from perfect, IQ is the single-best predictor of job performance we have – much better than Emotional Intelligence, the Big Five, Grit, etc. https://t.co/rKUgKDAAVx https://t.co/DWbVI8QSU3
5. Higher IQ is associated with a lower risk of death from most causes, including cardiovascular disease, respiratory disease, most forms of cancer, homicide, suicide, and accident. https://t.co/PJjGNyeQRA (N = 728,160)
1. IQ is one of the most heritable psychological traits – that is, individual differences in IQ are strongly associated with individual differences in genes (at least in fairly typical modern environments). https://t.co/3XxzW9bxLE
2. The heritability of IQ *increases* from childhood to adulthood. Meanwhile, the effect of the shared environment largely fades away. In other words, when it comes to IQ, nature becomes more important as we get older, nurture less. https://t.co/UqtS1lpw3n
3. IQ scores have been increasing for the last century or so, a phenomenon known as the Flynn effect. https://t.co/sCZvCst3hw (N ≈ 4 million)
(Note that the Flynn effect shows that IQ isn't 100% genetic; it doesn't show that it's 100% environmental.)
4. IQ predicts many important real world outcomes.
For example, though far from perfect, IQ is the single-best predictor of job performance we have – much better than Emotional Intelligence, the Big Five, Grit, etc. https://t.co/rKUgKDAAVx https://t.co/DWbVI8QSU3
5. Higher IQ is associated with a lower risk of death from most causes, including cardiovascular disease, respiratory disease, most forms of cancer, homicide, suicide, and accident. https://t.co/PJjGNyeQRA (N = 728,160)
